1-({5-(2-chlorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thien-2-yl}carbonyl)-4-phenylpiperidine-4-carboxamide

Base Information

Chemical Name:1-({5-(2-chlorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thien-2-yl}carbonyl)-4-phenylpiperidine-4-carboxamide
CAS No.:1207203-28-8
Molecular Formula:C₃₂H₃₁ClN₂O₄S
Molecular Weight:575.128
Hs Code.:

Synonyms:1-({5-(2-chlorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thien-2-yl}carbonyl)-4-phenylpiperidine-4-carboxamide

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Chemical Property of 1-({5-(2-chlorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thien-2-yl}carbonyl)-4-phenylpiperidine-4-carboxamide

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Technology Process of 1-({5-(2-chlorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thien-2-yl}carbonyl)-4-phenylpiperidine-4-carboxamide

There total 13 articles about 1-({5-(2-chlorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thien-2-yl}carbonyl)-4-phenylpiperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56243-25-5
1-benzyl-4-cyano-4-phenylpiperidine

: 1207203-28-8
1-({5-(2-chlorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thien-2-yl}carbonyl)-4-phenylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sulfuric acid / 1 h / 100 °C

1.2: Cooling with ice

2.1: cyclohexa-1,3-diene / palladium 10% on activated carbon / methanol / 6 h / Reflux

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 °C

4.1: hydrogenchloride; methanol / diethyl ether

With hydrogenchloride; methanol; sulfuric acid; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; cyclohexa-1,3-diene; triethylamine; palladium 10% on activated carbon; In methanol; diethyl ether; dichloromethane;

Reference yield:

: 1207203-80-2
1-{[5-(2-Chlorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

: 1207203-28-8
1-({5-(2-chlorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thien-2-yl}carbonyl)-4-phenylpiperidine-4-carboxamide

Guidance literature:: With hydrogenchloride; methanol; In diethyl ether;

Reference yield:

: 59084-07-0
1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide; hydrochloride

: 1207203-28-8
1-({5-(2-chlorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thien-2-yl}carbonyl)-4-phenylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: cyclohexa-1,3-diene / palladium 10% on activated carbon / methanol / 6 h / Reflux

2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 °C

3: hydrogenchloride; methanol / diethyl ether

With hydrogenchloride; methanol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; cyclohexa-1,3-diene; triethylamine; palladium 10% on activated carbon; In methanol; diethyl ether; dichloromethane;