2-chloro-6-phenyl-N-phenylcarbazole

Base Information

• Chemical Name: 2-chloro-6-phenyl-N-phenylcarbazole
• CAS No.: 1259388-66-3
• Molecular Formula: C₂₄H₁₆ClN
• Molecular Weight: 353.851
• Mol file: 1259388-66-3.mol

Synonyms:2-chloro-6-phenyl-N-phenylcarbazole

Chemical Property of 2-chloro-6-phenyl-N-phenylcarbazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-6-phenyl-N-phenylcarbazole

There total 6 articles about 2-chloro-6-phenyl-N-phenylcarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-chloro-6-bromo-N-phenylylcarbazole (1259388-64-1) + phenylboronic acid (98-80-6) → 2-chloro-6-phenyl-N-phenylcarbazole (1259388-66-3)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; for 5h; Inert atmosphere; Reflux;

Reference yield:

2-nitrophenyl bromide (577-19-5) → 2-chloro-6-phenyl-N-phenylcarbazole (1259388-66-3)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 8 h / Inert atmosphere; Reflux

2: triethyl phosphite / nitrogen / 24 h / 150 °C / Inert atmosphere

3: potassium carbonate / palladium diacetate; tri-tert-butyl phosphine / o-xylene / 24 h / 130 °C / Inert atmosphere

4: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C / Inert atmosphere

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 5 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; sodium carbonate; potassium carbonate; triethyl phosphite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; palladium diacetate; In tetrahydrofuran; dichloromethane; o-xylene; nitrogen; water;

Reference yield:

4'-chloro-2-nitrobiphenyl (6271-80-3) → 2-chloro-6-phenyl-N-phenylcarbazole (1259388-66-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triethyl phosphite / nitrogen / 24 h / 150 °C / Inert atmosphere

2: potassium carbonate / palladium diacetate; tri-tert-butyl phosphine / o-xylene / 24 h / 130 °C / Inert atmosphere

3: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 5 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; sodium carbonate; potassium carbonate; triethyl phosphite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; palladium diacetate; In tetrahydrofuran; dichloromethane; o-xylene; nitrogen; water;

upstream raw materials:

2-nitrophenyl bromide

4'-chloro-2-nitrobiphenyl

boronic acid 4-chlorophenyl monoester

2-chloro-6-bromo-N-phenylylcarbazole

Downstream raw materials:

C₄₂H₃₀N₂

Refernces