2-chloro-6-bromo-N-phenylylcarbazole

Base Information

• Chemical Name: 2-chloro-6-bromo-N-phenylylcarbazole
• CAS No.: 1259388-64-1
• Molecular Formula: C₁₈H₁₁BrClN
• Molecular Weight: 356.649
• Mol file: 1259388-64-1.mol

Synonyms:2-chloro-6-bromo-N-phenylylcarbazole

Chemical Property of 2-chloro-6-bromo-N-phenylylcarbazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-chloro-6-bromo-N-phenylylcarbazole

There total 5 articles about 2-chloro-6-bromo-N-phenylylcarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-chloro-9-phenylcarbazole (1259388-60-7) → 2-chloro-6-bromo-N-phenylylcarbazole (1259388-64-1)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

2-nitrophenyl bromide (577-19-5) → 2-chloro-6-bromo-N-phenylylcarbazole (1259388-64-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 8 h / Inert atmosphere; Reflux

2: triethyl phosphite / nitrogen / 24 h / 150 °C / Inert atmosphere

3: potassium carbonate / palladium diacetate; tri-tert-butyl phosphine / o-xylene / 24 h / 130 °C / Inert atmosphere

4: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; potassium carbonate; triethyl phosphite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; palladium diacetate; In tetrahydrofuran; dichloromethane; o-xylene; nitrogen; water;

Reference yield:

4'-chloro-2-nitrobiphenyl (6271-80-3) → 2-chloro-6-bromo-N-phenylylcarbazole (1259388-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethyl phosphite / nitrogen / 24 h / 150 °C / Inert atmosphere

2: potassium carbonate / palladium diacetate; tri-tert-butyl phosphine / o-xylene / 24 h / 130 °C / Inert atmosphere

3: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; potassium carbonate; triethyl phosphite; tri-tert-butyl phosphine; palladium diacetate; In dichloromethane; o-xylene; nitrogen;

upstream raw materials:

2-nitrophenyl bromide

2-chloro-9H-carbazole

4'-chloro-2-nitrobiphenyl

boronic acid 4-chlorophenyl monoester

Downstream raw materials:

2-chloro-6-phenyl-N-phenylcarbazole

Refernces