5-(3-(4-methoxyphenyl)isoxazol-5-ylmethyl)-5H benzo(4,5)imidazo(2,1-a)isoindole

Base Information

Chemical Name:5-(3-(4-methoxyphenyl)isoxazol-5-ylmethyl)-5H benzo(4,5)imidazo(2,1-a)isoindole
CAS No.:1346262-74-5
Molecular Formula:C₂₅H₁₉N₃O₂
Molecular Weight:393.445
Hs Code.:

Synonyms:5-(3-(4-methoxyphenyl)isoxazol-5-ylmethyl)-5H benzo(4,5)imidazo(2,1-a)isoindole

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Chemical Property of 5-(3-(4-methoxyphenyl)isoxazol-5-ylmethyl)-5H benzo(4,5)imidazo(2,1-a)isoindole

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Technology Process of 5-(3-(4-methoxyphenyl)isoxazol-5-ylmethyl)-5H benzo(4,5)imidazo(2,1-a)isoindole

There total 12 articles about 5-(3-(4-methoxyphenyl)isoxazol-5-ylmethyl)-5H benzo(4,5)imidazo(2,1-a)isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1346262-69-8
C₁₇H₁₂N₂

: 15500-73-9
4-methoxybenzonitrile oxide

: 1346262-74-5
5-(3-(4-methoxyphenyl)isoxazol-5-ylmethyl)-5H benzo(4,5)imidazo(2,1-a)isoindole

Guidance literature:: C₁₇H₁₂N₂; With triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride; In dichloromethane; at 0 - 5 ℃; for 0.166667h; Inert atmosphere;

4-methoxybenzonitrile oxide; In dichloromethane; at 0 - 20 ℃; for 0.583333h; regioselective reaction; Inert atmosphere;
DOI:10.1039/c1ob06072d

Reference yield:

: 1346262-69-8
C₁₇H₁₂N₂

: 15500-73-9
4-methoxybenzonitrile oxide

: C₂₅H₁₉N₃O₂

: 1346262-74-5
5-(3-(4-methoxyphenyl)isoxazol-5-ylmethyl)-5H benzo(4,5)imidazo(2,1-a)isoindole

Guidance literature:: C₁₇H₁₂N₂; With triethylamine; In dichloromethane; at 0 - 5 ℃; for 0.166667h; Inert atmosphere;

4-methoxybenzonitrile oxide; In dichloromethane; at 0 - 20 ℃; for 30.3h; Inert atmosphere;
DOI:10.1039/c1ob06072d

Reference yield:

: 3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9
p-methoxyl benzaldoxime

: 1346262-74-5
5-(3-(4-methoxyphenyl)isoxazol-5-ylmethyl)-5H benzo(4,5)imidazo(2,1-a)isoindole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / dichloromethane / 0.03 h / 0 - 5 °C

3.1: triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride / dichloromethane / 0.17 h / 0 - 5 °C / Inert atmosphere

3.2: 0.58 h / 0 - 20 °C / Inert atmosphere

With N-chloro-succinimide; triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1ob06072d