2-(4-fluorophenyl)-N-(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)acetamide

Base Information

Chemical Name:2-(4-fluorophenyl)-N-(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)acetamide
CAS No.:1258077-52-9
Molecular Formula:C₂₃H₁₈F₂N₄OS
Molecular Weight:436.485
Hs Code.:

Synonyms:2-(4-fluorophenyl)-N-(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)acetamide

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Chemical Property of 2-(4-fluorophenyl)-N-(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)acetamide

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Technology Process of 2-(4-fluorophenyl)-N-(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)acetamide

There total 3 articles about 2-(4-fluorophenyl)-N-(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.8%

: 944936-56-5
4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridin-2-ylamine

: 405-50-5
p-Fluorophenylacetic acid

: 1258077-52-9
2-(4-fluorophenyl)-N-(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)acetamide

Guidance literature:: p-Fluorophenylacetic acid; With 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; at 20 ℃; Inert atmosphere;

4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridin-2-ylamine; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm101623p

Reference yield:

: 549505-59-1
2-fluoro-4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridine

: 1258077-52-9
2-(4-fluorophenyl)-N-(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; ammonia / 18 h / 180 °C / Autoclave

2.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 20 °C / Inert atmosphere

2.2: 2 h / 120 °C / Inert atmosphere

With copper(l) iodide; ammonia; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one;
DOI:10.1021/jm101623p

Reference yield:

: 581098-38-6
4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione

: 1258077-52-9
2-(4-fluorophenyl)-N-(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol

2.1: copper(l) iodide; ammonia / 18 h / 180 °C / Autoclave

3.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 20 °C / Inert atmosphere

3.2: 2 h / 120 °C / Inert atmosphere

With copper(l) iodide; ammonia; potassium carbonate; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; methanol;
DOI:10.1021/jm101623p