Technology Process of (2,4-difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester
There total 5 articles about (2,4-difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,4-difluorophenol;
With
caesium carbonate;
In
acetonitrile;
for 0.5h;
Inert atmosphere;
bromo-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester;
In
acetonitrile;
at 25 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid / 3 h / 60 °C
2.1: potassium nitrate; chloro-trimethyl-silane / dichloromethane / 24 h / 50 °C / Sealed tube
3.1: N-Bromosuccinimide / tetrachloromethane / 48 h / Reflux
4.1: dichloromethane; hexane / 0.5 h / 0 - 20 °C / Inert atmosphere
5.1: caesium carbonate / acetonitrile / 0.5 h / Inert atmosphere
5.2: 3 h / 25 °C
With
N-Bromosuccinimide; chloro-trimethyl-silane; sulfuric acid; caesium carbonate; potassium nitrate;
In
tetrachloromethane; hexane; dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium nitrate; chloro-trimethyl-silane / dichloromethane / 24 h / 50 °C / Sealed tube
2.1: N-Bromosuccinimide / tetrachloromethane / 48 h / Reflux
3.1: dichloromethane; hexane / 0.5 h / 0 - 20 °C / Inert atmosphere
4.1: caesium carbonate / acetonitrile / 0.5 h / Inert atmosphere
4.2: 3 h / 25 °C
With
N-Bromosuccinimide; chloro-trimethyl-silane; caesium carbonate; potassium nitrate;
In
tetrachloromethane; hexane; dichloromethane; acetonitrile;