(2,4-difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester

Base Information

Chemical Name:(2,4-difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester
CAS No.:1328997-87-0
Molecular Formula:C₂₁H₂₃F₂NO₅S
Molecular Weight:439.48
Hs Code.:

Synonyms:(2,4-difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester

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Chemical Property of (2,4-difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester

Chemical Property:

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Technology Process of (2,4-difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester

There total 5 articles about (2,4-difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 367-27-1
2,4-difluorophenol

: 1328997-86-9
bromo-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester

: 1328997-87-0
(2,4-difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester

Guidance literature:: 2,4-difluorophenol; With caesium carbonate; In acetonitrile; for 0.5h; Inert atmosphere;

bromo-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester; In acetonitrile; at 25 ℃; for 3h;

Reference yield:

: 39161-84-7
4-mercaptophenylacetic acid

: 1328997-87-0
(2,4-difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 3 h / 60 °C

2.1: potassium nitrate; chloro-trimethyl-silane / dichloromethane / 24 h / 50 °C / Sealed tube

3.1: N-Bromosuccinimide / tetrachloromethane / 48 h / Reflux

4.1: dichloromethane; hexane / 0.5 h / 0 - 20 °C / Inert atmosphere

5.1: caesium carbonate / acetonitrile / 0.5 h / Inert atmosphere

5.2: 3 h / 25 °C

With N-Bromosuccinimide; chloro-trimethyl-silane; sulfuric acid; caesium carbonate; potassium nitrate; In tetrachloromethane; hexane; dichloromethane; acetonitrile;

Reference yield:

: 55863-28-0
4-mercapto-phenyl-acetic acid ethyl ester

: 1328997-87-0
(2,4-difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium nitrate; chloro-trimethyl-silane / dichloromethane / 24 h / 50 °C / Sealed tube

2.1: N-Bromosuccinimide / tetrachloromethane / 48 h / Reflux

3.1: dichloromethane; hexane / 0.5 h / 0 - 20 °C / Inert atmosphere

4.1: caesium carbonate / acetonitrile / 0.5 h / Inert atmosphere

4.2: 3 h / 25 °C

With N-Bromosuccinimide; chloro-trimethyl-silane; caesium carbonate; potassium nitrate; In tetrachloromethane; hexane; dichloromethane; acetonitrile;