(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid

Base Information

Chemical Name:(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid
CAS No.:960113-56-8
Molecular Formula:C₁₇H₁₉N₃O₆S
Molecular Weight:393.42
Hs Code.:

Synonyms:(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid

Chemical Property:

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Technology Process of (R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid

There total 6 articles about (R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: tert-butyl (R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoate

: 960113-56-8
(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid

Guidance literature:: With hydrogenchloride; In dichloromethane; at -10 - 20 ℃;
DOI:10.1021/jm0708533

Reference yield:

: 640-68-6,25609-85-2,7004-03-7,921-10-8
D-Val-OH

: 960113-56-8
(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / SOCl₂ / 20 °C

2: 98 percent / iPr₂NEt / acetonitrile / 48 h / 20 °C

3: 82 percent / K₂CO₃ / dimethylformamide / 20 °C

4: conc. HCl / 8 h / Heating

With hydrogenchloride; thionyl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jlcr.570

Reference yield:

D-Valine methyl ester hydrochloride: 7146-15-8
D-Valine methyl ester hydrochloride

: 960113-56-8
(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / iPr₂NEt / acetonitrile / 48 h / 20 °C

2: 82 percent / K₂CO₃ / dimethylformamide / 20 °C

3: conc. HCl / 8 h / Heating

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jlcr.570