(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-N-tert-butyloxy-3-methylbutanamide

Base Information

Chemical Name:(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-N-tert-butyloxy-3-methylbutanamide
CAS No.:477908-26-2
Molecular Formula:C₂₁H₂₈N₄O₆S
Molecular Weight:464.543
Hs Code.:

Synonyms:(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-N-tert-butyloxy-3-methylbutanamide

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Chemical Property of (R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-N-tert-butyloxy-3-methylbutanamide

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Technology Process of (R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-N-tert-butyloxy-3-methylbutanamide

There total 6 articles about (R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-N-tert-butyloxy-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 39684-28-1
O-(tert-butyl)hydroxylamine hydrochloride

: 960113-56-8
(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid

: 477908-26-2
(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-N-tert-butyloxy-3-methylbutanamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jm0708533

Reference yield:

: 640-68-6,25609-85-2,7004-03-7,921-10-8
D-Val-OH

: 477908-26-2
(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-N-tert-butyloxy-3-methylbutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / SOCl₂ / 20 °C

2: 98 percent / iPr₂NEt / acetonitrile / 48 h / 20 °C

3: 82 percent / K₂CO₃ / dimethylformamide / 20 °C

4: conc. HCl / 8 h / Heating

5: 0.65 g / EDC; HOBT; N-methylmorpholine / CH₂Cl₂ / 24 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; thionyl chloride; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jlcr.570

Reference yield:

D-Valine methyl ester hydrochloride: 7146-15-8
D-Valine methyl ester hydrochloride

: 477908-26-2
(R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-N-tert-butyloxy-3-methylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / iPr₂NEt / acetonitrile / 48 h / 20 °C

2: 82 percent / K₂CO₃ / dimethylformamide / 20 °C

3: conc. HCl / 8 h / Heating

4: 0.65 g / EDC; HOBT; N-methylmorpholine / CH₂Cl₂ / 24 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jlcr.570