tert-butyl 4-((N-(3-(benzyloxy)-4-(benzyloxycarbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((N-(3-(benzyloxy)-4-(benzyloxycarbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)piperidine-1-carboxylate
CAS No.:1357182-34-3
Molecular Formula:C₄₂H₄₉N₃O₈S
Molecular Weight:755.932
Hs Code.:

Synonyms:tert-butyl 4-((N-(3-(benzyloxy)-4-(benzyloxycarbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((N-(3-(benzyloxy)-4-(benzyloxycarbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((N-(3-(benzyloxy)-4-(benzyloxycarbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)piperidine-1-carboxylate

There total 9 articles about tert-butyl 4-((N-(3-(benzyloxy)-4-(benzyloxycarbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1331748-08-3
benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(piperidin-4-ylmethyl)acetamido)benzoate

: 1357182-34-3
tert-butyl 4-((N-(3-(benzyloxy)-4-(benzyloxycarbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)piperidine-1-carboxylate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/cmdc.201100194

Reference yield:

: 28126-01-4
methyl 2-(N,4-dimethylphenylsulfonam ido)acetate

: 1357182-34-3
tert-butyl 4-((N-(3-(benzyloxy)-4-(benzyloxycarbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere

2: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

3: dmap / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; lithium hydroxide monohydrate; water; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; dichloromethane; chloroform;
DOI:10.1002/cmdc.201100194

Reference yield:

: 2645-02-5
methyl tosylglycinate

: 1357182-34-3
tert-butyl 4-((N-(3-(benzyloxy)-4-(benzyloxycarbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere

3: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

4: dmap / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; lithium hydroxide monohydrate; water; caesium carbonate; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100194