28126-01-4

Upstream product

• 67-56-1 methanol 
• 667-08-3 N-Cyanomethyl-4,N-dimethyl-benzenesulfonamide 
• 2645-02-5 methyl tosylglycinate 
• 74-88-4 methyl iodide 
• 98-59-9 p-toluenesulfonyl chloride 
• 5473-12-1 N-methylglycine methylester 

Downstream Products

• 1051863-44-5 benzyl 2-(benzyloxy)-4-(N-(4-bromobenzyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate 
• 1051863-50-3 C₂₄H₂₃BrN₂O₆S 
• 1226496-04-3 4-(N-(4-cyclohexylbenzyl)-2-(N,4-dimethylphenylsulfon-amido)acetamido)-2-hydroxybenzoic acid 
• 1331747-54-6 4-(N-(4-(1-((4-cyanophenyl)sulfonyl)piperidin-4-yl)benzyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid 
• 1331747-51-3 4-(N-(4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid 
• 1251902-43-8 S₃I-201.2096 
• 1331747-52-4 4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(1-(pyrimidin-2-yl)piperidin-4-yl)benzyl)acetamido)-2-hydroxybenzoic acid 
• 1331747-53-5 C₃₇H₃₆N₄O₇S 
• 1357182-44-5 methyl 4'-((N-(3-(benzyloxy)-4-(benzyloxycarbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)biphenyl-3-carboxylate 
• 1357182-45-6 benzyl 2-(benzyloxy)-4-(N-((3'-cyanobiphenyl-4-yl)methyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate 
• 1357182-46-7 benzyl 2-(benzyloxy)-4-(N-((3'-carbamoylbiphenyl-4-yl)methyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate 
• 1357182-47-8 methyl 4'-((N-(3-(benzyloxy)-4-(benzyloxycarbonyl)phenyl)-2-(N,4-dimethylphenyl-sulfonamido)acetamido)methyl)biphenyl-4-carboxylate 
• 1357182-58-1 C₄₅H₄₀N₂O₈S 
• 1357182-48-9 benzyl 2-(benzyloxy)-4-(N-((4'-cyanobiphenyl-4-yl)methyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate 

Relevant academic research and scientific papers

Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of STAT protein

In one aspect, the invention relates to substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs, derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the com

STAT3 DIMERIZATION INHIBITORS

The subject matter disclosed herein relates to compositions and methods of making and using the compositions. In a further aspect, the subject matter disclosed herein relates to inhibitors of STAT3 dimerization. Methods of making these compositions as wel

Development of new N-arylbenzamides as STAT3 dimerization inhibitors

The O-tosylsalicylamide S3I-201 (10) was used as a starting point for design and synthesis of novel STAT-3 dimerization inhibitors with improved drug-like qualities. The phosphonic acid 12d and salicylic acids 13f, 13g with a shorter amide linker lacking

Antagonism of the Stat3-Stat3 Protein Dimer with Salicylic Acid Based Small Molecules

More than 50 new inhibitors of the oncogenic Stat3 protein were identified through a structure-activity relationship (SAR) study based on the previously identified inhibitor S3I-201 (IC50=86μM, Ki>300μM). A key structural feature of