5'-O--2'-deoxythymidine 3'-<4-(4'-methyl-2,2'-bipyridin-4-yl)butyl β-cyanoethyl phosphate>

Base Information

Chemical Name:5'-O--2'-deoxythymidine 3'-<4-(4'-methyl-2,2'-bipyridin-4-yl)butyl β-cyanoethyl phosphate>
CAS No.:142435-36-7
Molecular Formula:C₄₉H₅₂N₅O₁₀P
Molecular Weight:901.953
Hs Code.:

5'-O-<bis(4-methoxyphenyl)phenylmethyl>-2'-deoxythymidine 3'-<4-(4'-methyl-2,2'-bipyridin-4-yl)butyl β-cyanoethyl phosphate>

Synonyms:5'-O--2'-deoxythymidine 3'-<4-(4'-methyl-2,2'-bipyridin-4-yl)butyl β-cyanoethyl phosphate>

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Chemical Property of 5'-O--2'-deoxythymidine 3'-<4-(4'-methyl-2,2'-bipyridin-4-yl)butyl β-cyanoethyl phosphate>

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Technology Process of 5'-O--2'-deoxythymidine 3'-<4-(4'-methyl-2,2'-bipyridin-4-yl)butyl β-cyanoethyl phosphate>

There total 4 articles about 5'-O--2'-deoxythymidine 3'-<4-(4'-methyl-2,2'-bipyridin-4-yl)butyl β-cyanoethyl phosphate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142345-06-0
Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl ester

: 142435-36-7
5'-O--2'-deoxythymidine 3'-<4-(4'-methyl-2,2'-bipyridin-4-yl)butyl β-cyanoethyl phosphate>

Guidance literature:: With tert.-butylhydroperoxide; In dichloromethane; at 0 ℃; for 0.333333h; Yield given;
DOI:10.1021/ja00001a041

Reference yield:

: 1134-35-6
4,4'-dimethyl-2,2'-bipyridines

: 142435-36-7
5'-O--2'-deoxythymidine 3'-<4-(4'-methyl-2,2'-bipyridin-4-yl)butyl β-cyanoethyl phosphate>

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, 0 deg C, 1 h, 2.) RT, overnight

2: Dowex 50 W / CH₂Cl₂; methanol / 48 h / Heating

3: tetrazole / acetonitrile / 1 h / Ambient temperature

4: t-BuOOH / CH₂Cl₂; various solvent(s) / 0.33 h / 0 °C

With 1H-tetrazole; tert.-butylhydroperoxide; Dowex 50 W; lithium diisopropyl amide; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/ja00001a041

Reference yield:

: 118724-27-9
4-(4'-methyl-[2,2'-bipyridin]-4-yl)butan-1-ol

: 142435-36-7
5'-O--2'-deoxythymidine 3'-<4-(4'-methyl-2,2'-bipyridin-4-yl)butyl β-cyanoethyl phosphate>

Guidance literature:: Multi-step reaction with 2 steps

1: tetrazole / acetonitrile / 1 h / Ambient temperature

2: t-BuOOH / CH₂Cl₂; various solvent(s) / 0.33 h / 0 °C

With 1H-tetrazole; tert.-butylhydroperoxide; In dichloromethane; acetonitrile;
DOI:10.1021/ja00001a041