2-(5-methoxy-2,3-methylendioxyphenoxy)phenylacetic acid

Base Information

Chemical Name:2-(5-methoxy-2,3-methylendioxyphenoxy)phenylacetic acid
CAS No.:221177-65-7
Molecular Formula:C₁₆H₁₄O₆
Molecular Weight:302.284
Hs Code.:

Synonyms:2-(5-methoxy-2,3-methylendioxyphenoxy)phenylacetic acid

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Chemical Property of 2-(5-methoxy-2,3-methylendioxyphenoxy)phenylacetic acid

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Technology Process of 2-(5-methoxy-2,3-methylendioxyphenoxy)phenylacetic acid

There total 12 articles about 2-(5-methoxy-2,3-methylendioxyphenoxy)phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 221177-74-8
2-(5-methoxy-2,3-methylendioxyphenoxy)benzyl cyanide

: 221177-65-7
2-(5-methoxy-2,3-methylendioxyphenoxy)phenylacetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol; at 110 ℃; for 16h;

Reference yield:

: 116119-01-8
methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate

: 221177-65-7
2-(5-methoxy-2,3-methylendioxyphenoxy)phenylacetic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 68 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature

2: 90 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 1 h / 0 °C

3: 95 percent / MnO₂ / 1,2-dichloro-ethane / 12 h / sonication

4: 90 percent / m-CPBA, Na₂HPO₄ / CH₂Cl₂ / Heating

5: 93 percent / K₂CO₃ / acetone / 48 h / Heating

6: 97 percent / H₂ / Pd-C / ethyl acetate

7: 77 percent / K₂CO₃, Cu, CuI / various solvent(s) / 1 h / 120 °C

8: 95 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / 1 h / 0 °C

9: 76 percent / PBr₃ / CH₂Cl₂ / 1.5 h / 0 °C

10: 91 percent / dimethylsulfoxide / 1.5 h / 80 °C

11: 94 percent / aq. NaOH / ethanol; tetrahydrofuran / 16 h / 110 °C

With manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; disodium hydrogenphosphate; copper(l) iodide; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; phosphorus tribromide; copper; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 221177-68-0
7-(benzyloxy)benzo[d][1,3]dioxole-5-carbaldehyde

: 221177-65-7
2-(5-methoxy-2,3-methylendioxyphenoxy)phenylacetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / m-CPBA, Na₂HPO₄ / CH₂Cl₂ / Heating

2: 93 percent / K₂CO₃ / acetone / 48 h / Heating

3: 97 percent / H₂ / Pd-C / ethyl acetate

4: 77 percent / K₂CO₃, Cu, CuI / various solvent(s) / 1 h / 120 °C

5: 95 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / 1 h / 0 °C

6: 76 percent / PBr₃ / CH₂Cl₂ / 1.5 h / 0 °C

7: 91 percent / dimethylsulfoxide / 1.5 h / 80 °C

8: 94 percent / aq. NaOH / ethanol; tetrahydrofuran / 16 h / 110 °C

With sodium hydroxide; sodium tetrahydroborate; disodium hydrogenphosphate; copper(l) iodide; boron trifluoride diethyl etherate; hydrogen; phosphorus tribromide; copper; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetone;