benzyl (5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide

Base Information

Chemical Name:benzyl (5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide
CAS No.:1193782-24-9
Molecular Formula:C₂₂H₂₆FN₃O₄S
Molecular Weight:447.531
Hs Code.:

Synonyms:benzyl (5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide

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Chemical Property of benzyl (5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide

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Technology Process of benzyl (5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide

There total 6 articles about benzyl (5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1193782-23-8
benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide

: 74-88-4
methyl iodide

: 1193782-24-9
benzyl (5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide

Guidance literature:: benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm3009426

Reference yield: 89.0%

: 1193782-24-9
benzyl (5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide

Guidance literature:

Reference yield:

: 921599-74-8,852051-10-6
benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate

: 1193782-24-9
benzyl (5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / dichloromethane / 20 °C / Inert atmosphere

2.1: ammonia; hydrogen / methanol; water / 12 h / 2585.81 Torr / Inert atmosphere

3.1: 3-(imidazole-1-sulfonyl)-1-methyl-3H-imidazol-1-ium triflate / acetonitrile / 18 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

With ammonia; hydrogen; sodium hydride; acetic acid; 3-(imidazole-1-sulfonyl)-1-methyl-3H-imidazol-1-ium triflate; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3009426