10-((Z)-N-methyl-2-bromobut-2-enamido)-5-(phenylsulfonyl)-9,10-dihydro-6H-cyclohepta[b]indole

Base Information

Chemical Name:10-((Z)-N-methyl-2-bromobut-2-enamido)-5-(phenylsulfonyl)-9,10-dihydro-6H-cyclohepta[b]indole
CAS No.:1379799-60-6
Molecular Formula:C₂₄H₂₃BrN₂O₃S
Molecular Weight:499.428
Hs Code.:

Synonyms:10-((Z)-N-methyl-2-bromobut-2-enamido)-5-(phenylsulfonyl)-9,10-dihydro-6H-cyclohepta[b]indole

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Chemical Property of 10-((Z)-N-methyl-2-bromobut-2-enamido)-5-(phenylsulfonyl)-9,10-dihydro-6H-cyclohepta[b]indole

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Technology Process of 10-((Z)-N-methyl-2-bromobut-2-enamido)-5-(phenylsulfonyl)-9,10-dihydro-6H-cyclohepta[b]indole

There total 4 articles about 10-((Z)-N-methyl-2-bromobut-2-enamido)-5-(phenylsulfonyl)-9,10-dihydro-6H-cyclohepta[b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1379799-59-3
2-allyl-3-[(Z)-1-(N-methyl-2-bromobut-2-enamido)-3-butenyl]-1-(phenylsulfonyl)indole

: 1379799-60-6
10-((Z)-N-methyl-2-bromobut-2-enamido)-5-(phenylsulfonyl)-9,10-dihydro-6H-cyclohepta[b]indole

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 3h; chemoselective reaction; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2012.04.022

Reference yield:

: C₁₉H₁₈N₂O₂S

: 1379799-60-6
10-((Z)-N-methyl-2-bromobut-2-enamido)-5-(phenylsulfonyl)-9,10-dihydro-6H-cyclohepta[b]indole

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / -78 - 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 60 h / 20 °C / Inert atmosphere

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 3 h / Inert atmosphere; Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.tet.2012.04.022

Reference yield:

: 1379799-58-2
C₂₂H₂₄N₂O₂S

: 1379799-60-6
10-((Z)-N-methyl-2-bromobut-2-enamido)-5-(phenylsulfonyl)-9,10-dihydro-6H-cyclohepta[b]indole

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 60 h / 20 °C / Inert atmosphere

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 3 h / Inert atmosphere; Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.tet.2012.04.022