(3R,4S)-1-[(4-methylbenzene)sulfonyl]-4-phenyl-3-[(E)-2-phenylethenyl]azetidin-2-one

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Chemical Name:(3R,4S)-1-[(4-methylbenzene)sulfonyl]-4-phenyl-3-[(E)-2-phenylethenyl]azetidin-2-one
CAS No.:1207252-02-5
Molecular Formula:C₂₄H₂₁NO₃S
Molecular Weight:403.502
Hs Code.:

Synonyms:(3R,4S)-1-[(4-methylbenzene)sulfonyl]-4-phenyl-3-[(E)-2-phenylethenyl]azetidin-2-one

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Chemical Property of (3R,4S)-1-[(4-methylbenzene)sulfonyl]-4-phenyl-3-[(E)-2-phenylethenyl]azetidin-2-one

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Technology Process of (3R,4S)-1-[(4-methylbenzene)sulfonyl]-4-phenyl-3-[(E)-2-phenylethenyl]azetidin-2-one

There total 2 articles about (3R,4S)-1-[(4-methylbenzene)sulfonyl]-4-phenyl-3-[(E)-2-phenylethenyl]azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 201230-82-2
carbon monoxide

: 911028-87-0
(2R,3R)-2-phenyl-3-[(E)-2-phenyl-1-ethenyl]-1-tosylaziridine

: 1207252-02-5
(3R,4S)-1-[(4-methylbenzene)sulfonyl]-4-phenyl-3-[(E)-2-phenylethenyl]azetidin-2-one

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenylphosphine; In toluene; at 20 ℃; for 2h; under 750.075 Torr; optical yield given as %ee; diastereoselective reaction; Inert atmosphere;
DOI:10.1039/b920564k

Reference yield:

: 51608-60-7
N-(benzylidene)-p-methylbenzenesulfonamide

: 2243-53-0,59744-46-6,1914-58-5
trans-styrylacetic acid

: 1207252-02-5
(3R,4S)-1-[(4-methylbenzene)sulfonyl]-4-phenyl-3-[(E)-2-phenylethenyl]azetidin-2-one

: 1557264-03-5
(3S,4R)-1-[(4-methylbenzene)sulfonyl]-4-phenyl-3-[(E)-2-phenylethenyl]azetidin-2-one

Guidance literature:: trans-styrylacetic acid; With pivaloyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 - 25 ℃; for 0.166667h; Inert atmosphere;

N-(benzylidene)-p-methylbenzenesulfonamide; With 3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; In dichloromethane; at 20 - 25 ℃; for 1.5h; Overall yield = 68 %; Overall yield = 219 mg; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jo402591v