N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide
CAS No.:223757-41-3
Molecular Formula:C₂₇H₂₉N₃O₅S
Molecular Weight:507.61
Hs Code.:

<i>N</i>-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-1<i>H</i>-imidazol-2-yl]-4-methyl-benzenesulfonamide

Synonyms:N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide

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Chemical Property of N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide

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Technology Process of N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide

There total 9 articles about N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 223757-42-4
5-hydroxy-4-(4-methoxybenzyl)-1-(4-methoxymethylenoxy)benzyl-2-tosylamino-4,5-dihydroimidazole

: 223757-41-3
N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1021/jo9819382

Reference yield:

: 6515-21-5
4-methoxymethoxy-benzaldehyde

: 223757-41-3
N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent

2: 50 percent / H₂ / Pd/C

3: 1.) PPh₃ / 1.) Et₂O, room temperature, 12 h, 2.) Et₂O, room temperature, 1 h, 2.) Et₂O, room temperature, 12 h

4: 76 percent / DIBAL / tetrahydrofuran; hexane / 5 h / Heating

5: 98 percent / MsCl, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With hydrogen; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo9819382

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 223757-41-3
N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / NaH

2: 88 percent

3: 50 percent / H₂ / Pd/C

4: 1.) PPh₃ / 1.) Et₂O, room temperature, 12 h, 2.) Et₂O, room temperature, 1 h, 2.) Et₂O, room temperature, 12 h

5: 76 percent / DIBAL / tetrahydrofuran; hexane / 5 h / Heating

6: 98 percent / MsCl, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With hydrogen; sodium hydride; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo9819382