methyl (R)-2-(4-methoxyphenyl)-2-(2-nitrophenyl)sulfonylaminopropionate

Base Information

Chemical Name:methyl (R)-2-(4-methoxyphenyl)-2-(2-nitrophenyl)sulfonylaminopropionate
CAS No.:959694-61-2
Molecular Formula:C₁₇H₁₈N₂O₇S
Molecular Weight:394.405
Hs Code.:

Synonyms:methyl (R)-2-(4-methoxyphenyl)-2-(2-nitrophenyl)sulfonylaminopropionate

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Chemical Property of methyl (R)-2-(4-methoxyphenyl)-2-(2-nitrophenyl)sulfonylaminopropionate

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Technology Process of methyl (R)-2-(4-methoxyphenyl)-2-(2-nitrophenyl)sulfonylaminopropionate

There total 5 articles about methyl (R)-2-(4-methoxyphenyl)-2-(2-nitrophenyl)sulfonylaminopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 959694-59-8
methyl (R)-2-amino-2-(4-methoxyphenyl)propionate

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 959694-61-2
methyl (R)-2-(4-methoxyphenyl)-2-(2-nitrophenyl)sulfonylaminopropionate

Guidance literature:: With pyridine; at 20 ℃; for 1.75h; Inert atmosphere; Reflux;
DOI:10.1021/jm300249m

Reference yield:

: 197643-97-3
C₁₂H₁₅NO₄

: 959694-61-2
methyl (R)-2-(4-methoxyphenyl)-2-(2-nitrophenyl)sulfonylaminopropionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: (R)-1-phenyl-ethyl-amine / ethanol / 20 - 40 °C / Inert atmosphere

1.2: 0.75 h / 20 °C / pH 1 / Inert atmosphere

2.1: hydrogenchloride / 3 h / Inert atmosphere; Reflux

3.1: hydrogenchloride / 0 °C / Inert atmosphere; Reflux

3.2: Inert atmosphere

4.1: pyridine / 1.75 h / 20 °C / Inert atmosphere; Reflux

With pyridine; hydrogenchloride; (R)-1-phenyl-ethyl-amine; In ethanol;
DOI:10.1021/jm300249m

Reference yield:

: 22927-78-2
5-(4-methoxyphenyl)-5-methyl-2,4-imidazolidinedione

: 959694-61-2
methyl (R)-2-(4-methoxyphenyl)-2-(2-nitrophenyl)sulfonylaminopropionate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / 64 h / Inert atmosphere; Reflux

2.1: (R)-1-phenyl-ethyl-amine / ethanol / 20 - 40 °C / Inert atmosphere

2.2: 0.75 h / 20 °C / pH 1 / Inert atmosphere

3.1: hydrogenchloride / 3 h / Inert atmosphere; Reflux

4.1: hydrogenchloride / 0 °C / Inert atmosphere; Reflux

4.2: Inert atmosphere

5.1: pyridine / 1.75 h / 20 °C / Inert atmosphere; Reflux

With pyridine; hydrogenchloride; (R)-1-phenyl-ethyl-amine; sodium hydroxide; In ethanol;
DOI:10.1021/jm300249m