tert-butyl [4-(4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

Base Information

• Chemical Name: tert-butyl [4-(4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate
• CAS No.: 1191423-33-2
• Molecular Formula: C₃₀H₄₁N₅O₃Si
• Molecular Weight: 547.773
• Mol file: 1191423-33-2.mol

Synonyms:tert-butyl [4-(4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

Chemical Property of tert-butyl [4-(4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl [4-(4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

There total 4 articles about tert-butyl [4-(4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C30H45N5O3Si (1191423-20-7) → tert-butyl [4-(4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate (1191423-33-2)

Guidance literature:

C₃₀H₄₅N₅O₃Si; With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;

With manganese(IV) oxide;

DOI:10.1016/j.bmcl.2009.07.099

Reference yield:

C14H15NO (1191423-77-4) → tert-butyl [4-(4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate (1191423-33-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: ethanol / 50 °C / Inert atmosphere

3.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With potassium tert-butylate; dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethanol; N,N-dimethyl-formamide; 2.1: Pictet-Spengler cyclisation;

DOI:10.1248/cpb.59.579

Reference yield:

4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrole-2-carbaldehyde (1191423-01-4) → tert-butyl [4-(4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate (1191423-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 50 °C / Inert atmosphere

2.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethanol; 1.1: Pictet-Spengler cyclisation;

DOI:10.1248/cpb.59.579

upstream raw materials:

C₃₀H₄₅N₅O₃Si

C₁₄H₁₅NO

4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrole-2-carbaldehyde

(2-trimethylethylsilylethoxy)methyl chloride

Downstream raw materials:

tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

tert-butyl [4-(3,5-dibromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate