tert-butyl [4-(3,5-dibromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

Base Information

• Chemical Name: tert-butyl [4-(3,5-dibromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate
• CAS No.: 1361197-06-9
• Molecular Formula: C₃₀H₃₉Br₂N₅O₃Si
• Molecular Weight: 705.565
• Mol file: 1361197-06-9.mol

Synonyms:tert-butyl [4-(3,5-dibromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

Chemical Property of tert-butyl [4-(3,5-dibromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl [4-(3,5-dibromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

There total 6 articles about tert-butyl [4-(3,5-dibromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate (1361197-05-8) → tert-butyl [4-(3,5-dibromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate (1361197-06-9)

Guidance literature:

tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate; With tetra(n-butyl)ammonium tribromide; In methanol; at 0 - 20 ℃; Inert atmosphere;

With triethylamine; In methanol; at 0 ℃; Inert atmosphere;

DOI:10.1248/cpb.59.579

Reference yield:

C30H45N5O3Si (1191423-20-7) → tert-butyl [4-(3,5-dibromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate (1361197-06-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: tetra(n-butyl)ammonium tribromide / methanol / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: tetra(n-butyl)ammonium tribromide / methanol / 0 - 20 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

With tetra(n-butyl)ammonium tribromide; dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol;

DOI:10.1248/cpb.59.579

Reference yield:

tert-butyl [4-(4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate (1191423-33-2) → tert-butyl [4-(3,5-dibromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate (1361197-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetra(n-butyl)ammonium tribromide / methanol / 0 - 20 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: tetra(n-butyl)ammonium tribromide / methanol / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With tetra(n-butyl)ammonium tribromide; In methanol;

DOI:10.1248/cpb.59.579

upstream raw materials:

tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

C₁₄H₁₅NO

4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrole-2-carbaldehyde

C₃₀H₄₅N₅O₃Si

Downstream raw materials:

C₂HF₃O₂*C₁₉H₁₇Br₂N₅