tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

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Chemical Name:tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate
CAS No.:1361197-05-8
Molecular Formula:C₃₀H₄₀BrN₅O₃Si
Molecular Weight:626.669
Hs Code.:

Synonyms:tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

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Chemical Property of tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

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Technology Process of tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

There total 5 articles about tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1191423-33-2
tert-butyl [4-(4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

: 1361197-05-8
tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

Guidance literature:: tert-butyl [4-(4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate; With tetra(n-butyl)ammonium tribromide; In methanol; at 0 - 20 ℃; Inert atmosphere;

With triethylamine; In methanol; at 0 ℃; Inert atmosphere;
DOI:10.1248/cpb.59.579

Reference yield:

: 1191423-77-4
C₁₄H₁₅NO

: 1361197-05-8
tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: ethanol / 50 °C / Inert atmosphere

3.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: tetra(n-butyl)ammonium tribromide / methanol / 0 - 20 °C / Inert atmosphere

4.2: 0 °C / Inert atmosphere

With tetra(n-butyl)ammonium tribromide; potassium tert-butylate; dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; ethanol; N,N-dimethyl-formamide; 2.1: Pictet-Spengler cyclisation;
DOI:10.1248/cpb.59.579

Reference yield:

: 1191423-01-4
4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrole-2-carbaldehyde

: 1361197-05-8
tert-butyl [4-(5-bromo-4-(3-phenylpropyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 50 °C / Inert atmosphere

2.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: tetra(n-butyl)ammonium tribromide / methanol / 0 - 20 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

With tetra(n-butyl)ammonium tribromide; dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; ethanol; 1.1: Pictet-Spengler cyclisation;
DOI:10.1248/cpb.59.579