methyl 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylate

Base Information

Chemical Name:methyl 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylate
CAS No.:1093632-06-4
Molecular Formula:C₂₈H₂₃Cl₂N₃O₄
Molecular Weight:536.414
Hs Code.:

Synonyms:methyl 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylate

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Chemical Property of methyl 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylate

There total 4 articles about methyl 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 278597-30-1
[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methanol

: methyl 2-(4'-hydroxyphenyl)-1H-benzimidazole-4-carboxylate

: 1093632-06-4
methyl 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 18h;

Reference yield:

: 57113-91-4
methyl 3-nitroanthranilate

: 1093632-06-4
methyl 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 24 h / Inert atmosphere

2.1: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane; 1,2-dichloro-ethane / 2 h / 0 °C

2.2: 0.67 h / 120 °C

2.3: 20 °C

3.1: boron tribromide / dichloromethane / 2 h / 0 °C

3.2: Cooling with ice

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 18 h / 0 - 20 °C

With trifluoromethylsulfonic anhydride; di-isopropyl azodicarboxylate; hydrogen; boron tribromide; triphenylphosphine; Triphenylphosphine oxide; palladium 10% on activated carbon; In ethanol; dichloromethane; 1,2-dichloro-ethane; 4.1: Mitsunobu reaction;

Reference yield:

: 107582-20-7
2,3-diaminobenzoic acid methyl ester

: 1093632-06-4
methyl 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane; 1,2-dichloro-ethane / 2 h / 0 °C

1.2: 0.67 h / 120 °C

1.3: 20 °C

2.1: boron tribromide / dichloromethane / 2 h / 0 °C

2.2: Cooling with ice

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 18 h / 0 - 20 °C

With trifluoromethylsulfonic anhydride; di-isopropyl azodicarboxylate; boron tribromide; triphenylphosphine; Triphenylphosphine oxide; In dichloromethane; 1,2-dichloro-ethane; 3.1: Mitsunobu reaction;