2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylic acid

Base Information

Chemical Name:2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylic acid
CAS No.:1093631-62-9
Molecular Formula:C₂₇H₂₁Cl₂N₃O₄
Molecular Weight:522.387
Hs Code.:

Synonyms:2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylic acid

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Chemical Property of 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylic acid

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Technology Process of 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylic acid

There total 4 articles about 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093632-06-4
methyl 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylate

: 1093631-62-9
2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylic acid

Guidance literature:: methyl 2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylate; With lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; for 48h;

With sodium hydrogen sulfate; In water;

Reference yield:

: 57113-91-4
methyl 3-nitroanthranilate

: 1093631-62-9
2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 24 h / Inert atmosphere

2.1: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane; 1,2-dichloro-ethane / 2 h / 0 °C

2.2: 0.67 h / 120 °C

2.3: 20 °C

3.1: boron tribromide / dichloromethane / 2 h / 0 °C

3.2: Cooling with ice

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 18 h / 0 - 20 °C

5.1: lithium hydroxide / tetrahydrofuran; 1,4-dioxane / 48 h

With trifluoromethylsulfonic anhydride; di-isopropyl azodicarboxylate; hydrogen; boron tribromide; triphenylphosphine; Triphenylphosphine oxide; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane; 4.1: Mitsunobu reaction;

Reference yield:

: 107582-20-7
2,3-diaminobenzoic acid methyl ester

: 1093631-62-9
2-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-benzimidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane; 1,2-dichloro-ethane / 2 h / 0 °C

1.2: 0.67 h / 120 °C

1.3: 20 °C

2.1: boron tribromide / dichloromethane / 2 h / 0 °C

2.2: Cooling with ice

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 18 h / 0 - 20 °C

4.1: lithium hydroxide / tetrahydrofuran; 1,4-dioxane / 48 h

With trifluoromethylsulfonic anhydride; di-isopropyl azodicarboxylate; boron tribromide; triphenylphosphine; Triphenylphosphine oxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; 3.1: Mitsunobu reaction;