3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid

Base Information

Chemical Name:3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid
CAS No.:937054-43-8
Molecular Formula:C₂₃H₂₁ClFNO₅
Molecular Weight:445.875
Hs Code.:

Synonyms:3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid

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Chemical Property of 3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid

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Technology Process of 3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid

There total 10 articles about 3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937057-67-5
3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanenitrile

: 937054-43-8
3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid

Guidance literature:: 3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanenitrile; With sodium hydroxide; water; isopropyl alcohol; for 24h; Heating / reflux;

With hydrogenchloride; water; at 0 ℃;

Reference yield:

: 937057-60-8
(5-chloro-3-fluoro-2-pyrrol-1-ylphenyl)-(2,3-dimethoxyphenyl)methanol

: 937054-43-8
3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: manganese(IV) oxide / dichloromethane / 14 h / 20 °C / Heating / reflux

2.1: trichlorophosphate / 0.25 h / 0 - 20 °C

2.2: 2.08 h / 0 - 50 °C

2.3: 0.5 h / 50 °C

3.1: toluene / 1 h / Heating / reflux

4.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

4.2: 0 °C

5.1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C

6.1: Resolution of racemate

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

7.2: 0 °C

8.1: triethylamine / dichloromethane / 1 h / 0 °C

9.1: dimethyl sulfoxide / 13 h / 50 °C

10.1: sodium hydroxide; water; isopropyl alcohol / 24 h / Heating / reflux

10.2: 0 °C

With manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; water; triethylamine; isopropyl alcohol; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 937057-62-0
1-[4-Chloro-2-(2,3-dimethoxybenzoyl)-6-fluorophenyl]-1H-pyrrolo-2-carbaldehyde

: 937054-43-8
3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene / 1 h / Heating / reflux

2.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

2.2: 0 °C

3.1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C

4.1: Resolution of racemate

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

5.2: 0 °C

6.1: triethylamine / dichloromethane / 1 h / 0 °C

7.1: dimethyl sulfoxide / 13 h / 50 °C

8.1: sodium hydroxide; water; isopropyl alcohol / 24 h / Heating / reflux

8.2: 0 °C

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; water; triethylamine; isopropyl alcohol; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;