3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanenitrile

Base Information

Chemical Name:3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanenitrile
CAS No.:937057-67-5
Molecular Formula:C₂₃H₂₀ClFN₂O₃
Molecular Weight:426.875
Hs Code.:

Synonyms:3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanenitrile

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Chemical Property of 3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanenitrile

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Technology Process of 3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanenitrile

There total 9 articles about 3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937057-66-4
2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl methanesulfonate

: 143-33-9,25596-52-5
sodium cyanide

: 937057-67-5
3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanenitrile

Guidance literature:: In dimethyl sulfoxide; at 50 ℃; for 13h;

Reference yield:

: 937057-60-8
(5-chloro-3-fluoro-2-pyrrol-1-ylphenyl)-(2,3-dimethoxyphenyl)methanol

: 937057-67-5
3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanenitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: manganese(IV) oxide / dichloromethane / 14 h / 20 °C / Heating / reflux

2.1: trichlorophosphate / 0.25 h / 0 - 20 °C

2.2: 2.08 h / 0 - 50 °C

2.3: 0.5 h / 50 °C

3.1: toluene / 1 h / Heating / reflux

4.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

4.2: 0 °C

5.1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C

6.1: Resolution of racemate

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

7.2: 0 °C

8.1: triethylamine / dichloromethane / 1 h / 0 °C

9.1: dimethyl sulfoxide / 13 h / 50 °C

With manganese(IV) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 937057-62-0
1-[4-Chloro-2-(2,3-dimethoxybenzoyl)-6-fluorophenyl]-1H-pyrrolo-2-carbaldehyde

: 937057-67-5
3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 1 h / Heating / reflux

2.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

2.2: 0 °C

3.1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C

4.1: Resolution of racemate

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

5.2: 0 °C

6.1: triethylamine / dichloromethane / 1 h / 0 °C

7.1: dimethyl sulfoxide / 13 h / 50 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;