(3S,5R)-5-(biphenyl-4-yl-methyl)-3-(hydroxymethyl)-3-methylpyrrolidin-2-one

Base Information

Chemical Name:(3S,5R)-5-(biphenyl-4-yl-methyl)-3-(hydroxymethyl)-3-methylpyrrolidin-2-one
CAS No.:1394050-28-2
Molecular Formula:C₁₉H₂₁NO₂
Molecular Weight:295.381
Hs Code.:

Synonyms:(3S,5R)-5-(biphenyl-4-yl-methyl)-3-(hydroxymethyl)-3-methylpyrrolidin-2-one

Suppliers and Price of (3S,5R)-5-(biphenyl-4-yl-methyl)-3-(hydroxymethyl)-3-methylpyrrolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (3S,5R)-5-(biphenyl-4-yl-methyl)-3-(hydroxymethyl)-3-methylpyrrolidin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3S,5R)-5-(biphenyl-4-yl-methyl)-3-(hydroxymethyl)-3-methylpyrrolidin-2-one

There total 7 articles about (3S,5R)-5-(biphenyl-4-yl-methyl)-3-(hydroxymethyl)-3-methylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1038925-08-4
(3R,5R)-5-(biphenyl-4-yl)methyl-3-methyl-2-oxopyrrolidine-3-carboxylic acid

: 1394050-28-2
(3S,5R)-5-(biphenyl-4-yl-methyl)-3-(hydroxymethyl)-3-methylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0.33 h / 0 - 5 °C / Inert atmosphere

2: sodium tetrahydroborate / water; tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; sodium tetrahydroborate; In tetrahydrofuran; water;

Reference yield:

: 1394050-66-8
C₂₄H₂₇NO₅

: 1394050-28-2
(3S,5R)-5-(biphenyl-4-yl-methyl)-3-(hydroxymethyl)-3-methylpyrrolidin-2-one

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 ℃; for 0.333333h; Inert atmosphere;

Reference yield:

: 128779-47-5
(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 1394050-28-2
(3S,5R)-5-(biphenyl-4-yl-methyl)-3-(hydroxymethyl)-3-methylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 9 h / -5 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

2.2: 2 h / -5 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 23 °C / Inert atmosphere

4.1: hydrogenchloride / cyclopentyl methyl ether / 24 h / 0 - 20 °C / Inert atmosphere

5.1: 2-methyltetrahydrofuran; cyclopentyl methyl ether / 20 °C / Inert atmosphere

6.1: 4-methyl-morpholine / tetrahydrofuran / 0.33 h / 0 - 5 °C / Inert atmosphere

7.1: sodium tetrahydroborate / water; tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; dmap; sodium tetrahydroborate; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; cyclopentyl methyl ether; water; N,N-dimethyl-formamide;