(2S,4R)-4-amino-5-biphenyl-4-yl-2-(hydroxymethyl)-2-methylpentanoic acid (5-methyl-2-oxo-[1,3]-dioxol-4-yl)methyl ester hydrochloride

Base Information

Chemical Name:(2S,4R)-4-amino-5-biphenyl-4-yl-2-(hydroxymethyl)-2-methylpentanoic acid (5-methyl-2-oxo-[1,3]-dioxol-4-yl)methyl ester hydrochloride
CAS No.:1394050-31-7
Molecular Formula:C₂₄H₂₇NO₆*ClH
Molecular Weight:461.942
Hs Code.:

Synonyms:(2S,4R)-4-amino-5-biphenyl-4-yl-2-(hydroxymethyl)-2-methylpentanoic acid (5-methyl-2-oxo-[1,3]-dioxol-4-yl)methyl ester hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-4-amino-5-biphenyl-4-yl-2-(hydroxymethyl)-2-methylpentanoic acid (5-methyl-2-oxo-[1,3]-dioxol-4-yl)methyl ester hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,4R)-4-amino-5-biphenyl-4-yl-2-(hydroxymethyl)-2-methylpentanoic acid (5-methyl-2-oxo-[1,3]-dioxol-4-yl)methyl ester hydrochloride

There total 10 articles about (2S,4R)-4-amino-5-biphenyl-4-yl-2-(hydroxymethyl)-2-methylpentanoic acid (5-methyl-2-oxo-[1,3]-dioxol-4-yl)methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394050-47-5
C₃₄H₄₃NO₉

: 1394050-31-7
(2S,4R)-4-amino-5-biphenyl-4-yl-2-(hydroxymethyl)-2-methylpentanoic acid (5-methyl-2-oxo-[1,3]-dioxol-4-yl)methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; cyclopentyl methyl ether; Inert atmosphere;

Reference yield:

: 1383026-37-6
[(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester

: 1394050-31-7
(2S,4R)-4-amino-5-biphenyl-4-yl-2-(hydroxymethyl)-2-methylpentanoic acid (5-methyl-2-oxo-[1,3]-dioxol-4-yl)methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 11 steps

1.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

1.2: 2 h / -5 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 23 °C / Inert atmosphere

3.1: hydrogenchloride / cyclopentyl methyl ether / 24 h / 0 - 20 °C / Inert atmosphere

4.1: 2-methyltetrahydrofuran; cyclopentyl methyl ether / 20 °C / Inert atmosphere

5.1: 4-methyl-morpholine / tetrahydrofuran / 0.33 h / 0 - 5 °C / Inert atmosphere

6.1: sodium tetrahydroborate / water; tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

7.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

8.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

8.2: 5 - 20 °C / Inert atmosphere

9.1: water; lithium hydroxide / tetrahydrofuran / 5 - 35 °C / Inert atmosphere

10.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

10.2: 19 h / 0 - 20.2 °C / Inert atmosphere

11.1: hydrogenchloride / dichloromethane; cyclopentyl methyl ether / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; water; sodium hexamethyldisilazane; potassium carbonate; acetic acid; lithium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; cyclopentyl methyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 1383026-42-3
[(S)-2-biphenyl-4-yl-1-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylmethyl)ethyl]carbamic acid t-butyl ester

: 1394050-31-7
(2S,4R)-4-amino-5-biphenyl-4-yl-2-(hydroxymethyl)-2-methylpentanoic acid (5-methyl-2-oxo-[1,3]-dioxol-4-yl)methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 23 °C / Inert atmosphere

2.1: hydrogenchloride / cyclopentyl methyl ether / 24 h / 0 - 20 °C / Inert atmosphere

3.1: 2-methyltetrahydrofuran; cyclopentyl methyl ether / 20 °C / Inert atmosphere

4.1: 4-methyl-morpholine / tetrahydrofuran / 0.33 h / 0 - 5 °C / Inert atmosphere

5.1: sodium tetrahydroborate / water; tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

6.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

7.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

7.2: 5 - 20 °C / Inert atmosphere

8.1: water; lithium hydroxide / tetrahydrofuran / 5 - 35 °C / Inert atmosphere

9.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

9.2: 19 h / 0 - 20.2 °C / Inert atmosphere

10.1: hydrogenchloride / dichloromethane; cyclopentyl methyl ether / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; water; sodium hexamethyldisilazane; potassium carbonate; lithium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; cyclopentyl methyl ether; water; N,N-dimethyl-formamide;