2-[(4-{2,2-dimethyl-1-[4-(1H-pyrazol-3-yl)phenyl]propyl}phenoxy)methyl]pyridine

Base Information

Chemical Name:2-[(4-{2,2-dimethyl-1-[4-(1H-pyrazol-3-yl)phenyl]propyl}phenoxy)methyl]pyridine
CAS No.:1094042-67-7
Molecular Formula:C₂₆H₂₇N₃O
Molecular Weight:397.52
Hs Code.:

Synonyms:2-[(4-{2,2-dimethyl-1-[4-(1H-pyrazol-3-yl)phenyl]propyl}phenoxy)methyl]pyridine

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Chemical Property of 2-[(4-{2,2-dimethyl-1-[4-(1H-pyrazol-3-yl)phenyl]propyl}phenoxy)methyl]pyridine

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Technology Process of 2-[(4-{2,2-dimethyl-1-[4-(1H-pyrazol-3-yl)phenyl]propyl}phenoxy)methyl]pyridine

There total 12 articles about 2-[(4-{2,2-dimethyl-1-[4-(1H-pyrazol-3-yl)phenyl]propyl}phenoxy)methyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2E)-3-(dimethylamino)-1-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)prop-2-en-1-one

: 1094042-67-7
2-[(4-{2,2-dimethyl-1-[4-(1H-pyrazol-3-yl)phenyl]propyl}phenoxy)methyl]pyridine

Guidance literature:: With hydrazine hydrate; In ethanol; at 80 ℃; for 2h;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1094042-67-7
2-[(4-{2,2-dimethyl-1-[4-(1H-pyrazol-3-yl)phenyl]propyl}phenoxy)methyl]pyridine

Guidance literature:: Multi-step reaction with 11 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0 °C

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 50 °C

2.2: 20 °C

2.3: 0.5 h

3.1: iodine; magnesium; lithium chloride / tetrahydrofuran / 50 °C

3.2: 0 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide

5.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 72 h / 760.05 Torr

6.1: Chiralpak_.(R). AD / methanol / Resolution of racemate

7.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide

8.1: trimethylaluminum / dichloromethane; toluene / 0.25 h / 20 °C

9.1: tetrahydrofuran; diethyl ether / 0 °C

10.1: ethanol / 0.67 h / 150 °C / Microwave irradiation

11.1: hydrazine hydrate / ethanol / 2 h / 80 °C

With lithium hydroxide monohydrate; water; hydrogen; iodine; trimethylaluminum; sodium carbonate; caesium carbonate; hydrazine hydrate; magnesium; potassium iodide; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium hydroxide, 20 wt% on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 131379-16-3
4-(ethoxycarbonyl)phenylzinc iodide

: 1094042-67-7
2-[(4-{2,2-dimethyl-1-[4-(1H-pyrazol-3-yl)phenyl]propyl}phenoxy)methyl]pyridine

Guidance literature:: Multi-step reaction with 11 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0 °C

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 50 °C

2.2: 20 °C

2.3: 0.5 h

3.1: iodine; magnesium; lithium chloride / tetrahydrofuran / 50 °C

3.2: 0 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide

5.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 72 h / 760.05 Torr

6.1: Chiralpak_.(R). AD / methanol / Resolution of racemate

7.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide

8.1: trimethylaluminum / dichloromethane; toluene / 0.25 h / 20 °C

9.1: tetrahydrofuran; diethyl ether / 0 °C

10.1: ethanol / 0.67 h / 150 °C / Microwave irradiation

11.1: hydrazine hydrate / ethanol / 2 h / 80 °C

With lithium hydroxide monohydrate; water; hydrogen; iodine; trimethylaluminum; sodium carbonate; caesium carbonate; hydrazine hydrate; magnesium; potassium iodide; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium hydroxide, 20 wt% on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;