1-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio) pyridin-2-yl)thiourea

Base Information

Chemical Name:1-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio) pyridin-2-yl)thiourea
CAS No.:953045-84-6
Molecular Formula:C₁₉H₁₅BrFN₃O₂S₂
Molecular Weight:480.381
Hs Code.:

Synonyms:1-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio) pyridin-2-yl)thiourea

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Chemical Property of 1-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio) pyridin-2-yl)thiourea

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Technology Process of 1-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio) pyridin-2-yl)thiourea

There total 8 articles about 1-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio) pyridin-2-yl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.8%

: 953045-83-5
1-benzoyl-3-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)pyridin-2-yl)thiourea

: 953045-84-6
1-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio) pyridin-2-yl)thiourea

Guidance literature:: With sodium hydroxide; In ethanol; at 50 ℃;

Reference yield:

: 573675-25-9
5-bromo-3-nitropyridine-2-carbonitrile

: 953045-84-6
1-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio) pyridin-2-yl)thiourea

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 0.33 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.1: potassium hydroxide; water / ethanol / Heating / reflux

3.2: 20 °C

4.1: diphenyl phosphoryl azide; triethylamine / toluene / 0.17 h / 100 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 20 °C

6.1: tetrahydrofuran / 20 °C

7.1: sodium hydroxide / ethanol / 50 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; diphenyl phosphoryl azide; water; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1065609-78-0
5-bromo-3-(2-bromo-4-fluorophenoxy)picolinonitrile

: 953045-84-6
1-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio) pyridin-2-yl)thiourea

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.1: potassium hydroxide; water / ethanol / Heating / reflux

2.2: 20 °C

3.1: diphenyl phosphoryl azide; triethylamine / toluene / 0.17 h / 100 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 20 °C

5.1: tetrahydrofuran / 20 °C

6.1: sodium hydroxide / ethanol / 50 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; diphenyl phosphoryl azide; water; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;