benzyl 2-<(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-methylsulfonyl-2-oxo-1-azetidinyl>-3-methyl-2-butenoate

Base Information

Chemical Name:benzyl 2-<(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-methylsulfonyl-2-oxo-1-azetidinyl>-3-methyl-2-butenoate
CAS No.:85253-94-7
Molecular Formula:C₂₄H₃₇NO₆SSi
Molecular Weight:495.712
Hs Code.:

Synonyms:benzyl 2-<(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-methylsulfonyl-2-oxo-1-azetidinyl>-3-methyl-2-butenoate

Suppliers and Price of benzyl 2-<(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-methylsulfonyl-2-oxo-1-azetidinyl>-3-methyl-2-butenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl 2-<(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-methylsulfonyl-2-oxo-1-azetidinyl>-3-methyl-2-butenoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl 2-<(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-methylsulfonyl-2-oxo-1-azetidinyl>-3-methyl-2-butenoate

There total 13 articles about benzyl 2-<(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-methylsulfonyl-2-oxo-1-azetidinyl>-3-methyl-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 85253-94-7
benzyl 2-<(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-methylsulfonyl-2-oxo-1-azetidinyl>-3-methyl-2-butenoate

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 20 h / Ambient temperature

2: m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature

3: 1,5-diazabicyclo<4.3.0>non-5-ene / CH₂Cl₂ / 1 h / 20 - 25 °C

4: potassium t-butoxide / tetrahydrofuran; dimethylformamide / 0.5 h

With 1H-imidazole; potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; DBN; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.59.1887

Reference yield:

: 15058-70-5
6-diazopenicillanic acid benzyl ester

: 85253-94-7
benzyl 2-<(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-methylsulfonyl-2-oxo-1-azetidinyl>-3-methyl-2-butenoate

Guidance literature:: Multi-step reaction with 7 steps

1: BF₃*OEt₂ / CH₂Cl₂

2: BuLi / tetrahydrofuran / 0.67 h / -78 °C

3: 100 percent / Bu₃SnH / AIBN / tetrahydrofuran / 2 h / 60 °C

4: imidazole / dimethylformamide / 20 h / Ambient temperature

5: m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature

6: 1,5-diazabicyclo<4.3.0>non-5-ene / CH₂Cl₂ / 1 h / 20 - 25 °C

7: potassium t-butoxide / tetrahydrofuran; dimethylformamide / 0.5 h

With 1H-imidazole; n-butyllithium; boron trifluoride diethyl etherate; potassium tert-butylate; tri-n-butyl-tin hydride; 3-chloro-benzenecarboperoxoic acid; 2,2'-azobis(isobutyronitrile); DBN; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.59.1887

Reference yield:

: 83162-14-5
(2S,5R,6R)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

: 85253-94-7
benzyl 2-<(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-methylsulfonyl-2-oxo-1-azetidinyl>-3-methyl-2-butenoate

Guidance literature:: Multi-step reaction with 3 steps

1: m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature

2: 1,5-diazabicyclo<4.3.0>non-5-ene / CH₂Cl₂ / 1 h / 20 - 25 °C

3: potassium t-butoxide / tetrahydrofuran; dimethylformamide / 0.5 h

With potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; DBN; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.59.1887