N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycine

Base Information

Chemical Name:N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycine
CAS No.:1114591-15-9
Molecular Formula:C₂₄H₃₁N₅O₃
Molecular Weight:437.542
Hs Code.:

Synonyms:N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycine

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Chemical Property of N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycine

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Technology Process of N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycine

There total 9 articles about N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1114591-08-0
tert-butyl N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycinate

: 76-05-1
trifluoroacetic acid

: 1114591-15-9
N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycine

Guidance literature:: In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 1114592-06-1
methyl 2-chloro-6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate

: 1114591-15-9
N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycine

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium formate / palladium 10% on activated carbon / water; isopropyl alcohol / 0.75 h / 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 1 h / 20 °C

2.2: pH 6

3.1: CF₃O₃S^(1-)*C₅H₅NPol⁽¹⁺⁾; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: manganese(IV) oxide / dichloromethane / 18 h / 20 °C

5.1: triethylamine / dichloromethane / 0.03 h

5.2: 20 h / 20 °C

6.1: dichloromethane / 24 h / 20 °C

With manganese(IV) oxide; lithium hydroxide; CF₃O₃S^(1-)*C₅H₅NPol⁽¹⁺⁾; water; ammonium formate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 99175-39-0
cyclohexyl-cyclopropylmethyl-amine; hydrochloride

: 1114591-15-9
N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycine

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran / 48 h / 0 - 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / water; isopropyl alcohol / 0.75 h / 20 °C

3.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 1 h / 20 °C

3.2: pH 6

4.1: CF₃O₃S^(1-)*C₅H₅NPol⁽¹⁺⁾; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: manganese(IV) oxide / dichloromethane / 18 h / 20 °C

6.1: triethylamine / dichloromethane / 0.03 h

6.2: 20 h / 20 °C

7.1: dichloromethane / 24 h / 20 °C

With manganese(IV) oxide; lithium hydroxide; CF₃O₃S^(1-)*C₅H₅NPol⁽¹⁺⁾; water; ammonium formate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;