tert-butyl N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycinate

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Chemical Name:tert-butyl N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycinate
CAS No.:1114591-08-0
Molecular Formula:C₂₈H₃₉N₅O₃
Molecular Weight:493.649
Hs Code.:

Synonyms:tert-butyl N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycinate

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Chemical Property of tert-butyl N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycinate

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Technology Process of tert-butyl N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycinate

There total 8 articles about tert-butyl N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1114592-19-6
6-[cyclohexyl(cyclopropylmethyl)amino]-N-(4-formylphenyl)pyrimidine-4-carboxamide

: 27532-96-3
glycine tert-butyl ester hydrochloride

: 1114591-08-0
tert-butyl N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycinate

Guidance literature:: 6-[cyclohexyl(cyclopropylmethyl)amino]-N-(4-formylphenyl)pyrimidine-4-carboxamide; glycine tert-butyl ester hydrochloride; With triethylamine; In dichloromethane; for 0.0333333h;

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 20h;

With sodium hydroxide; In water; ethyl acetate;

Reference yield:

: 1114592-06-1
methyl 2-chloro-6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate

: 1114591-08-0
tert-butyl N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium formate / palladium 10% on activated carbon / water; isopropyl alcohol / 0.75 h / 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 1 h / 20 °C

2.2: pH 6

3.1: CF₃O₃S^(1-)*C₅H₅NPol⁽¹⁺⁾; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: manganese(IV) oxide / dichloromethane / 18 h / 20 °C

5.1: triethylamine / dichloromethane / 0.03 h

5.2: 20 h / 20 °C

With manganese(IV) oxide; lithium hydroxide; CF₃O₃S^(1-)*C₅H₅NPol⁽¹⁺⁾; water; ammonium formate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 99175-39-0
cyclohexyl-cyclopropylmethyl-amine; hydrochloride

: 1114591-08-0
tert-butyl N-{4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}qlycinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran / 48 h / 0 - 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / water; isopropyl alcohol / 0.75 h / 20 °C

3.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 1 h / 20 °C

3.2: pH 6

4.1: CF₃O₃S^(1-)*C₅H₅NPol⁽¹⁺⁾; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: manganese(IV) oxide / dichloromethane / 18 h / 20 °C

6.1: triethylamine / dichloromethane / 0.03 h

6.2: 20 h / 20 °C

With manganese(IV) oxide; lithium hydroxide; CF₃O₃S^(1-)*C₅H₅NPol⁽¹⁺⁾; water; ammonium formate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;