Technology Process of N-(6-(2,5-dimethylpyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride
There total 6 articles about N-(6-(2,5-dimethylpyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
8-bromo-6-phenylimidazo[1,2-b]pyridazine; 6-(2,5-dimethylpyrrolidin-1-yl)pyridin-2-amine;
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,4-dioxane;
at 100 ℃;
for 16h;
Inert atmosphere;
Sealed tube;
With
hydrogenchloride;
In
water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: water / 0.5 h / 205 °C / Microwave irradiation
2: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,4-dioxane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tris-(dibenzylideneacetone)dipalladium(0); XPhos; sodium carbonate / water; 1,4-dioxane / 6 h / 100 °C / Inert atmosphere
2: bromine; sodium hydrogencarbonate / methanol / 16.5 h / 20 °C
3: toluene-4-sulfonic acid / isopropyl alcohol / 40 h / 80 °C
4: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube
With
tris-(dibenzylideneacetone)dipalladium(0); bromine; sodium hydrogencarbonate; sodium carbonate; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; XPhos;
In
1,4-dioxane; methanol; water; isopropyl alcohol;