1-[(4-Methoxyphenyl)sulfonyl]-2-pyrrolidinemethanol

Base Information

Chemical Name:1-[(4-Methoxyphenyl)sulfonyl]-2-pyrrolidinemethanol
CAS No.:202751-30-2
Molecular Formula:C₁₂H₁₇NO₄S
Molecular Weight:271.337
Hs Code.:
DSSTox Substance ID:DTXSID501222822

Synonyms:1-[(4-Methoxyphenyl)sulfonyl]-2-pyrrolidinemethanol;SCHEMBL6325815;QENDKLNKUVHFSD-UHFFFAOYSA-N;DTXSID501222822;AKOS010668977;202751-30-2;1-[(4-methoxyphenyl)sulfonyl]-2-(hydroxymethyl)pyrrolidine;1-[(4-methoxyphenyl)sulfonyl)-2-(hydroxymethyl)-pyrrolidine

Suppliers and Price of 1-[(4-Methoxyphenyl)sulfonyl]-2-pyrrolidinemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(4-Methoxyphenyl)sulfonyl]-2-pyrrolidinemethanol

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:271.08782920
Heavy Atom Count:18
Complexity:357

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)S(=O)(=O)N2CCCC2CO

Technology Process of 1-[(4-Methoxyphenyl)sulfonyl]-2-pyrrolidinemethanol

There total 3 articles about 1-[(4-Methoxyphenyl)sulfonyl]-2-pyrrolidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: racemic 1-[(4-methoxyphenyl)sulfonyl]-2-carboxypyrrolidine

: 202751-29-9
1-((4-methoxyphenyl)sulfonyl)pyrrolidine-2-carboxylic acid

: 202751-30-2
(1-((4-methoxyphenyl)sulfonyl)pyrrolidin-2-yl)methanol

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; diethyl ether; water; ethyl acetate;

Reference yield:

: methyl 1-((4-methoxyphenyl)sulfonyl)pyrrolidine-2-carboxylate

: 202751-30-2
(1-((4-methoxyphenyl)sulfonyl)pyrrolidin-2-yl)methanol

Guidance literature:: With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; at 0 - 20 ℃;
DOI:10.1002/chem.201805878

Reference yield:

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 202751-30-2
(1-((4-methoxyphenyl)sulfonyl)pyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 10.5 h / 0 - 20 °C

2: lithium chloride; sodium tetrahydroborate / tetrahydrofuran; ethanol / 0 - 20 °C

With dmap; sodium tetrahydroborate; triethylamine; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/chem.201805878