1-(4-METHOXY-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 1-(4-METHOXY-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID
• CAS No.: 202751-29-9
• Molecular Formula: C₁₂H₁₅NO₅S
• Molecular Weight: 285.321
• Mol file: 202751-29-9.mol

Synonyms:1-((4-methoxyphenyl)sulfonyl)pyrrolidine-2-carboxylic acid

Chemical Property of 1-(4-METHOXY-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

Useful:

Technology Process of 1-(4-METHOXY-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID

There total 2 articles about 1-(4-METHOXY-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-methoxy-phenyl-sulphonyl chloride (98-68-0) + rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → 1-((4-methoxyphenyl)sulfonyl)pyrrolidine-2-carboxylic acid (202751-29-9)

Guidance literature:

With dmap; sodium carbonate; In water; at 20 ℃; for 3.5h; pH=9 - 10;

DOI:10.14233/ajchem.2020.22957

Reference yield:

methoxybenzene (100-66-3) → 1-((4-methoxyphenyl)sulfonyl)pyrrolidine-2-carboxylic acid (202751-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / chloroform / 75 h / 0 - 20 °C

2: sodium carbonate; dmap / water / 3.5 h / 20 °C / pH 9 - 10

With chlorosulfonic acid; dmap; sodium carbonate; In chloroform; water;

DOI:10.14233/ajchem.2020.22957

Reference yield: 86.0%

phenyl 3-phenylprop-2-ynoate (100954-03-8) + 1-((4-methoxyphenyl)sulfonyl)pyrrolidine-2-carboxylic acid (202751-29-9) → 3‐((4‐methoxyphenyl)sulfonyl)‐4-phenyl-2H-chromen-2-one

Guidance literature:

With dipotassium peroxodisulfate; silver nitrate; In water; acetonitrile; at 50 ℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube; Darkness;

DOI:10.1002/ejoc.201800901

upstream raw materials:

4-methoxy-phenyl-sulphonyl chloride

rac-Pro-OH

methoxybenzene

Downstream raw materials:

1-[(4-methoxyphenyl)sulfonyl]-N-(3-thioxo-3H-1,2,4-dithiazol-5-yl)-2-pyrrolidine carboxamide

(1-((4-methoxyphenyl)sulfonyl)pyrrolidin-2-yl)methanol