Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester

Base Information

• Chemical Name: Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester
• CAS No.: 911128-69-3
• Molecular Formula: C₄₄H₆₀N₅O₈PSi
• Molecular Weight: 846.048
• Mol file: 911128-69-3.mol

Synonyms:Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester

Chemical Property of Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester

There total 7 articles about Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

bis(N,N-diisopropylamino)methoxyphosphine (92611-10-4) + 9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one (127212-34-4) → Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester (911128-69-3)

Guidance literature:

With pyridinium trifluroacetate; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ja0613714

Reference yield:

9-[(2R,3R,4R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one → Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester (911128-69-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / pyridinium trifluoroacetate / CH₂Cl₂ / 1 h / 20 °C

With pyridinium trifluroacetate; In dichloromethane;

DOI:10.1021/ja0613714

Reference yield:

3',5'-O-(di-tert-butylsilanylidene)inosine → Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester (911128-69-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: imidazole / dimethylformamide / 0.5 h / 20 °C

1.2: 13.2 g / dimethylformamide / 2.5 h / 60 °C

2.1: HF*pyridine / pyridine / 3 h / cooling

3.1: 80 percent / pyridinium trifluoroacetate / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; pyridinium trifluroacetate; pyridine hydrogenfluoride; In pyridine; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja0613714

upstream raw materials:

bis(N,N-diisopropylamino)methoxyphosphine

9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

9-[2,2-di-tert-butyl-7-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furo[3,2-d][1,3,2]dioxasilin-6-yl]-1,9-dihydro-purin-6-one

4,4'-dimethoxytrityl chloride