9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

Base Information

Chemical Name:9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one
CAS No.:127212-34-4
Molecular Formula:C₃₇H₄₄N₄O₇Si
Molecular Weight:684.864
Hs Code.:

9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

Synonyms:9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

Suppliers and Price of 9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

There total 12 articles about 9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 119898-59-8
9-[(2R,3R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3,4-dihydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

: 127212-34-4
9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

: 9-[(2R,3R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}-3-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

Guidance literature:: With pyridine; silver nitrate; In tetrahydrofuran; at 20 ℃;
DOI:10.1080/00397910008086956

Reference yield:

: 58-63-9
Inosine

: 127212-34-4
9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylformamide / 0.5 h / cooling

2.1: imidazole / dimethylformamide / 0.5 h / 20 °C

2.2: 13.2 g / dimethylformamide / 2.5 h / 60 °C

3.1: HF*pyridine / pyridine / 3 h / cooling

With 1H-imidazole; pyridine hydrogenfluoride; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/ja0613714