5-ethyl-2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

Base Information

Chemical Name:5-ethyl-2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one
CAS No.:1352569-92-6
Molecular Formula:C₂₂H₂₄N₂O₅S
Molecular Weight:428.509
Hs Code.:

Synonyms:5-ethyl-2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

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Chemical Property of 5-ethyl-2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

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Technology Process of 5-ethyl-2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

There total 5 articles about 5-ethyl-2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1352570-89-8
3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)benzamidine

: 105-54-4
butanoic acid ethyl ester

: 109-94-4
formic acid ethyl ester

: 1352569-92-6
5-ethyl-2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

Guidance literature:: butanoic acid ethyl ester; formic acid ethyl ester; With sodium hydride; In diethyl ether; mineral oil; at 20 ℃; for 24h;

3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)benzamidine; In ethanol; at 75 ℃;

With hydrogenchloride; In ethanol; water; pH=~ 2;

Reference yield:

: 3-[isopropoxy]-5-[4-(methylsulfonyl)phenoxy]benzonitrile

: 1352569-92-6
5-ethyl-2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium chloride; trimethylaluminum / toluene / 36 h / 110 °C

2.1: sodium hydride / diethyl ether; mineral oil / 24 h / 20 °C

2.2: 75 °C

2.3: pH ~ 2

With trimethylaluminum; sodium hydride; ammonium chloride; In diethyl ether; toluene; mineral oil;

Reference yield:

: 19179-36-3
3,5-dihydroxycyanobenzene

: 1352569-92-6
5-ethyl-2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 - 20 °C

1.2: 65 - 150 °C

2.1: potassium carbonate / N,N-dimethyl-formamide; mineral oil / 4 h / 65 °C

3.1: ammonium chloride; trimethylaluminum / toluene / 36 h / 110 °C

4.1: sodium hydride / diethyl ether; mineral oil / 24 h / 20 °C

4.2: 75 °C

4.3: pH ~ 2

With trimethylaluminum; sodium hydride; potassium carbonate; ammonium chloride; In diethyl ether; N,N-dimethyl-formamide; toluene; mineral oil;