trans-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

• Chemical Name: trans-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
• CAS No.: 88156-80-3
• Molecular Formula: C₁₉H₂₂N₂O₄
• Molecular Weight: 342.395

Synonyms:trans-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Chemical Property of trans-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Chemical Property:

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Technology Process of trans-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 3 articles about trans-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide (88156-78-9) → cis-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (88156-79-0) + trans-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (88156-80-3)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 35 ℃; for 43h;

DOI:10.1021/jo00178a001

Reference yield:

(+/-)-N-Methylsalsoline (65644-76-0) → trans-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (88156-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / acetonitrile / Heating

2: potassium tert-butoxide / 2-methyl-propan-2-ol / 43 h / 35 °C

With potassium tert-butylate; In acetonitrile; tert-butyl alcohol;

DOI:10.1021/jo00178a001

Reference yield:

1-bromomethyl-4-nitro-benzene (100-11-8) → trans-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (88156-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / acetonitrile / Heating

2: potassium tert-butoxide / 2-methyl-propan-2-ol / 43 h / 35 °C

With potassium tert-butylate; In acetonitrile; tert-butyl alcohol;

DOI:10.1021/jo00178a001

upstream raw materials:

trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide

(+/-)-N-Methylsalsoline

1-bromomethyl-4-nitro-benzene

Downstream raw materials:

trans-7,8-Dimethoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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