(+/-)-N-Methylsalsoline

Base Information

• Chemical Name: (+/-)-N-Methylsalsoline
• CAS No.: 65644-76-0
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• Mol file: 65644-76-0.mol

Synonyms:(+/-)-N-Methylsalsoline

Chemical Property of (+/-)-N-Methylsalsoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N-Methylsalsoline

There total 1 articles about (+/-)-N-Methylsalsoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (+/-)-salsolinol (525-72-4,27740-96-1,53622-83-6,78579-88-1) → N-Nor-1-methylcorypalline (4593-97-9) + (+/-)-N-Methylsalsoline (65644-76-0) + 6-methoxy-1,2-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-ol (19641-12-4) + rac-salsoline (89-31-6,20405-58-7,76419-97-1,101467-40-7)

Guidance literature:

In diethyl ether; Yield given. Further byproducts given. Yields of byproduct given; Ambient temperature;

DOI:10.1016/S0031-9422(00)98233-5

Reference yield: 91.0%

(+/-)-N-Methylsalsoline (65644-76-0) + 1-bromomethyl-4-nitro-benzene (100-11-8) → trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide (88156-78-9)

Guidance literature:

In acetonitrile; Heating;

DOI:10.1021/jo00178a001

Reference yield:

(+/-)-N-Methylsalsoline (65644-76-0) → cis-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (88156-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / acetonitrile / Heating

2: 52 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 43 h / 35 °C

With potassium tert-butylate; In acetonitrile; tert-butyl alcohol;

DOI:10.1021/jo00178a001

upstream raw materials:

diazomethane

(+/-)-salsolinol

Downstream raw materials:

trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide

cis-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

trans-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

cis-7,8-Dimethoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine