trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide

Base Information

Chemical Name:trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide
CAS No.:88156-78-9
Molecular Formula:Br*C₁₉H₂₃N₂O₄
Molecular Weight:423.307
Hs Code.:

Synonyms:trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide

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Chemical Property of trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide

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Technology Process of trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide

There total 1 articles about trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 65644-76-0
(+/-)-N-Methylsalsoline

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 88156-78-9
trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide

Guidance literature:: In acetonitrile; Heating;
DOI:10.1021/jo00178a001

Reference yield: 52.0%

: 88156-78-9
trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide

: 88156-79-0
cis-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

: 88156-80-3
trans-7-Hydroxy-8-methoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; at 35 ℃; for 43h;
DOI:10.1021/jo00178a001

Reference yield:

: 88156-78-9
trans-6-Hydroxy-7-methoxy-1,2-dimethyl-2-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide

: 88156-81-4
cis-7,8-Dimethoxy-1,3-dimethyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 43 h / 35 °C

2: diethyl ether; CHCl₃; methanol / 48 h

With potassium tert-butylate; In methanol; diethyl ether; chloroform; tert-butyl alcohol;
DOI:10.1021/jo00178a001