tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-2-phenylethylcarbamate

Base Information

Chemical Name:tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-2-phenylethylcarbamate
CAS No.:839718-57-9
Molecular Formula:C₂₅H₃₃NO₇
Molecular Weight:459.54
Hs Code.:

Synonyms:tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-2-phenylethylcarbamate

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Chemical Property of tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-2-phenylethylcarbamate

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Technology Process of tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-2-phenylethylcarbamate

There total 3 articles about tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-2-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 253353-08-1
1,1-dimethylethyl α-(1,1-dimethylethoxy)carbonylamino-3,4-dioxo-2-(1-methylethoxy)-1-cyclobutene-1-acetate

: 100-39-0
benzyl bromide

: 839718-57-9
tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-2-phenylethylcarbamate

Guidance literature:: 1,1-dimethylethyl α-(1,1-dimethylethoxy)carbonylamino-3,4-dioxo-2-(1-methylethoxy)-1-cyclobutene-1-acetate; With potassium carbonate; In acetonitrile; at 20 ℃; for 0.0833333h;

benzyl bromide; With tetra-(n-butyl)ammonium iodide; In acetonitrile; at 20 ℃; for 0.5h;
DOI:10.1055/s-2005-872109

Reference yield:

: tert-butoxycarbonylamino-(1,2-diisopropoxy-3,4-dioxo-cyclobutyl)-acetic acid tert-butyl ester

: 839718-57-9
tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-2-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 84 percent / aq. HCl / CH₂Cl₂ / 4 h / 20 °C

2.1: K₂CO₃ / acetonitrile / 0.08 h / 20 °C

2.2: 90 percent / tetrabutylammonium iodide / acetonitrile / 0.5 h / 20 °C

With hydrogenchloride; potassium carbonate; In dichloromethane; acetonitrile;
DOI:10.1055/s-2005-872109

Reference yield:

: 111652-20-1
N-(tert-butoxycarbonyl)glycine tert-butyl ester

: 839718-57-9
tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-2-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

1.2: 72 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 84 percent / aq. HCl / CH₂Cl₂ / 4 h / 20 °C

3.1: K₂CO₃ / acetonitrile / 0.08 h / 20 °C

3.2: 90 percent / tetrabutylammonium iodide / acetonitrile / 0.5 h / 20 °C

With hydrogenchloride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1055/s-2005-872109