111652-20-1Relevant articles and documents
Synthesis of regio- and stereoselectively deuterium-labelled derivatives of l-glutamate semialdehyde for studies on carbapenem biosynthesis
Ducho, Christian,Hamed, Refaat B.,Batchelar, Edward T.,Sorensen, John L.,Odell, Barbara,Schofield, Christopher J.
, p. 2770 - 2779 (2009)
l-Glutamate semialdehyde (l-GSA) is an intermediate in biosynthetic pathways including those leading to the carbapenem antibiotics. We describe studies on asymmetric deuteration or hydrogenation of appropriate didehydro-amino acid precursors for the stereoselective synthesis of C-2- and/or C-3-[2H]-labelled l-GSA suitable for use in mechanistic studies. Regioselective deuterium incorporation into the 5-position of l-GSA was achieved using a labelled form of the Schwartz reagent (Cp2Zr 2HCl). 4,4-Dideuterated and fully backbone deuterated l-GSAs were prepared. The application of the labelled l-GSA derivatives to biosynthetic studies was exemplified by the chemo-enzymatic preparation of selectively deuterated trans-carboxymethylprolines using two different carboxymethylproline synthases (CarB and ThnE), enzymes that catalyse early steps in the biosynthesis of two carbapenems: (5R)-carbapenem-3-carboxylate and thienamycin, respectively. The Royal Society of Chemistry 2009.
Studies on the transformation of azido-group to N-(t-butoxycarbonyl)amino group via Staudinger reaction
Afonso, Carlos A. M.
, p. 261 - 276 (1998)
By a simple and direct sequence, treatment of primary azides with tri-n-butylphosphine, followed by addition of di-t-butyl dicarbonate (Boc2O) affords, N-(t-Butoxycarbonyl)amines 2 in moderate to good overall yields. For secondary azides the fo
Preparation method of tert-butyl glycine
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Paragraph 0037-0039, (2021/11/06)
The invention discloses a preparation method of tert-butyl glycine, and belongs to the technical field of organic synthesis. The raw materials are easily available, the process is simple, the process is simple, the reaction conditions are mild, the requirement for equipment is low, the total yield is up to 85 - 93%, and a significant amount of double-substituted by-products are effectively avoided in the direct reaction with ammonia in the traditional process.
Diamine precursor process for the production of compounds
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Paragraph 0119; 0120; 0121; 0122; 0123; 0124, (2016/10/07)
Provided is an inexpensive, simple, and efficient method for preparing, from a starting material, a nitro compound constituting a diamine precursor compound which is a starting material for producing a polyamic acid and/or polyimide. Compound (1) is reacted according to reaction formula (1) with di-tert-butyl dicarbonate ((Boc)2O) to produce compound (2) (1) (where R1 represents -CH2COOR or -CH2Ph(-Z)m (where Z is a substituent group for a phenyl group (Ph) and m ranges from 0 to 5), and R represents a lower alkyl group or alkali metal atom), compound (2) is then reacted according to reaction formula (2) with H-A-CH2-X to produce compound (3) (2) (where A represents -C=C- or -CH=CH-, and X represents a leaving substituent group), and compound (3) is then subjected to a coupling reaction according to reaction formula (3) with compound (4) to produce compound (5) (3) (where Y represents a leaving substituent group).
