3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-N-(4-methoxyphenyl)acrylamide

Base Information

Chemical Name:3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-N-(4-methoxyphenyl)acrylamide
CAS No.:1007543-20-5
Molecular Formula:C₂₅H₂₀BrN₃O₂
Molecular Weight:474.357
Hs Code.:

Synonyms:3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-N-(4-methoxyphenyl)acrylamide

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Chemical Property of 3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-N-(4-methoxyphenyl)acrylamide

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Technology Process of 3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-N-(4-methoxyphenyl)acrylamide

There total 4 articles about 3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-N-(4-methoxyphenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 104-94-9
4-methoxy-aniline

: 108446-73-7,519137-41-8
(E)-3-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-acrylic acid

: 1007543-20-5
3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-N-(4-methoxyphenyl)acrylamide

Guidance literature:: With dmap; potassium carbonate; In dichloromethane; for 12h; Heating;
DOI:10.1016/j.bmc.2012.05.031

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1007543-20-5
3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-N-(4-methoxyphenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium acetate / ethanol / 3 h / 50 - 60 °C

2: trichlorophosphate / 50 - 60 °C / Cooling

3: piperidine; pyridine / 5 h / 40 - 50 °C

4: dmap; potassium carbonate / dichloromethane / 12 h / Heating

With piperidine; pyridine; dmap; sodium acetate; potassium carbonate; trichlorophosphate; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2012.05.031

Reference yield:

: 59-88-1
phenylhydrazine hydrochloride

: 1007543-20-5
3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-N-(4-methoxyphenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium acetate / ethanol / 3 h / 50 - 60 °C

2: trichlorophosphate / 50 - 60 °C / Cooling

3: piperidine; pyridine / 5 h / 40 - 50 °C

4: dmap; potassium carbonate / dichloromethane / 12 h / Heating

With piperidine; pyridine; dmap; sodium acetate; potassium carbonate; trichlorophosphate; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2012.05.031