3-benzyloxy-6-[2-(tert-butyl-dimethyl-silanyloxy)-2-methoxycarbonyl-vinyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-2-(4,5,7,8,9-pentamethoxy-naphtho[2,3-b]furan-2-yl)-ethyl]-2-methoxy-benzoic acid methyl ester

Base Information

Chemical Name:3-benzyloxy-6-[2-(tert-butyl-dimethyl-silanyloxy)-2-methoxycarbonyl-vinyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-2-(4,5,7,8,9-pentamethoxy-naphtho[2,3-b]furan-2-yl)-ethyl]-2-methoxy-benzoic acid methyl ester
CAS No.:404356-61-2
Molecular Formula:C₆₁H₇₂O₁₄Si₂
Molecular Weight:1085.41
Hs Code.:

3-benzyloxy-6-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-methoxycarbonyl-vinyl]-4-[2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-2-(4,5,7,8,9-pentamethoxy-naphtho[2,3-<i>b</i>]furan-2-yl)-ethyl]-2-methoxy-benzoic acid methyl ester

Synonyms:3-benzyloxy-6-[2-(tert-butyl-dimethyl-silanyloxy)-2-methoxycarbonyl-vinyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-2-(4,5,7,8,9-pentamethoxy-naphtho[2,3-b]furan-2-yl)-ethyl]-2-methoxy-benzoic acid methyl ester

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Chemical Property of 3-benzyloxy-6-[2-(tert-butyl-dimethyl-silanyloxy)-2-methoxycarbonyl-vinyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-2-(4,5,7,8,9-pentamethoxy-naphtho[2,3-b]furan-2-yl)-ethyl]-2-methoxy-benzoic acid methyl ester

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Technology Process of 3-benzyloxy-6-[2-(tert-butyl-dimethyl-silanyloxy)-2-methoxycarbonyl-vinyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-2-(4,5,7,8,9-pentamethoxy-naphtho[2,3-b]furan-2-yl)-ethyl]-2-methoxy-benzoic acid methyl ester

There total 13 articles about 3-benzyloxy-6-[2-(tert-butyl-dimethyl-silanyloxy)-2-methoxycarbonyl-vinyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-2-(4,5,7,8,9-pentamethoxy-naphtho[2,3-b]furan-2-yl)-ethyl]-2-methoxy-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 78186-95-5
methyl 2-(tert-butyldimethylsiloxy)-2-(dimethoxyphosphoryl)acetate

: 404356-77-0
3-benzyloxy-4-[2-(tert-butyl-diphenyl-silanyloxy)-2-(4,5,7,8,9-pentamethoxy-naphtho[2,3-b]furan-2-yl)-ethyl]-6-formyl-2-methoxy-benzoic acid methyl ester

: 404356-61-2
3-benzyloxy-6-[2-(tert-butyl-dimethyl-silanyloxy)-2-methoxycarbonyl-vinyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-2-(4,5,7,8,9-pentamethoxy-naphtho[2,3-b]furan-2-yl)-ethyl]-2-methoxy-benzoic acid methyl ester

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 25 ℃;
DOI:10.1002/1521-3773(20011217)40:24<4709::AID-ANIE4709>3.0.CO;2-Q

Reference yield:

: 89984-24-7
2-bromo-4-hydroxy-3-methoxy-benzaldehyde

: 404356-61-2
3-benzyloxy-6-[2-(tert-butyl-dimethyl-silanyloxy)-2-methoxycarbonyl-vinyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-2-(4,5,7,8,9-pentamethoxy-naphtho[2,3-b]furan-2-yl)-ethyl]-2-methoxy-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 95 percent / benzene / Heating

2: 95 percent / K₂CO₃ / acetone / Heating

3: decahydronaphthalene / 240 °C

4: K₂CO₃ / acetone / Heating

5: 97 percent / OsO₄; NMO; H₂O / acetone

6: 88 percent / aq. NaIO₄ / acetone

7: tetrahydrofuran / -78 °C

8: imidazole / CH₂Cl₂

9: n-BuLi / tetrahydrofuran / -78 °C

10: benzene; methanol

11: 95 percent / aq. HCl / acetone; tetrahydrofuran

12: 96 percent / LiHMDS / tetrahydrofuran / 25 °C

With 1H-imidazole; hydrogenchloride; sodium periodate; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; water; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; acetone; decalin; benzene; 3: Claisen rearrangement / 12: Horner-Emmons reaction;
DOI:10.1002/1521-3773(20011217)40:24<4709::AID-ANIE4709>3.0.CO;2-Q

Reference yield:

: 100-39-0
benzyl bromide

: 404356-61-2
3-benzyloxy-6-[2-(tert-butyl-dimethyl-silanyloxy)-2-methoxycarbonyl-vinyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-2-(4,5,7,8,9-pentamethoxy-naphtho[2,3-b]furan-2-yl)-ethyl]-2-methoxy-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: K₂CO₃ / acetone / Heating

2: 97 percent / OsO₄; NMO; H₂O / acetone

3: 88 percent / aq. NaIO₄ / acetone

4: tetrahydrofuran / -78 °C

5: imidazole / CH₂Cl₂

6: n-BuLi / tetrahydrofuran / -78 °C

7: benzene; methanol

8: 95 percent / aq. HCl / acetone; tetrahydrofuran

9: 96 percent / LiHMDS / tetrahydrofuran / 25 °C

With 1H-imidazole; hydrogenchloride; sodium periodate; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; water; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; acetone; benzene; 9: Horner-Emmons reaction;
DOI:10.1002/1521-3773(20011217)40:24<4709::AID-ANIE4709>3.0.CO;2-Q