[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]azanium;chloride

Base Information

• Chemical Name: [(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]azanium;chloride
• CAS No.: 2153-98-2
• Molecular Formula: C9H13 N O . Cl H
• Molecular Weight: 187.669
• Hs Code.: 2922199090
• Mol file: 2153-98-2.mol

Synonyms:

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of [(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]azanium;chloride

Chemical Property:

• Appearance/Colour: solid ,white
• Melting Point: 172-175 °C
• Flash Point: 9℃
• PSA: 46.25000
• LogP: 2.56950
• Storage Temp.: ?20°C
• Solubility.: H2O: ~20 mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 187.0763918
• Heavy Atom Count: 12
• Complexity: 110

Purity/Quality:

Safty Information:

• Hazard Codes: Xn,T,F
• Statements: 22-39/23/24/25-23/24/25-11
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C1=CC=CC=C1)O)[NH3+].[Cl-]
• Isomeric SMILES: C[C@@H]([C@H](C1=CC=CC=C1)O)[NH3+].[Cl-]
• Uses: In the optical resolution of externally compensated acids.

Technology Process of [(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]azanium;chloride

There total 22 articles about [(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4S,5S)-4-methyl-2,5-diphenyl-4,5-dihydro-1,3-oxazole (257952-52-6) → (-)-Norpseudoephedrine hydrochloride (2153-98-2)

Guidance literature:

With hydrogenchloride; for 30h; Heating;

DOI:10.1016/S0957-4166(99)00432-2

Reference yield: 80.0%

1-phenyl-2-phthalimido-1-propanol (59686-10-1) → (-)-Norpseudoephedrine hydrochloride (2153-98-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 0.75h; Heating;

Reference yield: 74.0%

threo-1-benzoyloxy-1-phenyl-2-propylammonium chloride (38222-78-5) → threo-1-phenyl-1-hydroxy-2-propylammonium chloride (154-41-6,1485-15-0,2153-98-2,3198-15-0,4345-16-8,40626-29-7,53631-70-2,53643-20-2,54705-32-7)

Guidance literature:

With hydrogenchloride; for 30h; Heating;

upstream raw materials:

(1R,2S)-norephedrine

1-phenyl-2-phthalimido-1-propanol

(4S,5S)-4-methyl-2,5-diphenyl-4,5-dihydro-1,3-oxazole

(1R,2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)benzamide

Downstream raw materials:

(1S,2S)-1-phenyl-1-trimethylsilyloxy-2-amino-propane

(S)-2--1-phenylpropane

trimethylsilyl ether of (1S,2S)-N-trifluoroacetamidonorpseudoephedrine

N-[(1S,2S)-2-((S)-1-Allyl-nonyloxy)-1-methyl-2-phenyl-ethyl]-2,2,2-trifluoro-acetamide