Oxazole, 4,5-dihydro-4-methyl-2,5-diphenyl-, (4S,5S)-

Base Information

Chemical Name:Oxazole, 4,5-dihydro-4-methyl-2,5-diphenyl-, (4S,5S)-
CAS No.:257952-52-6
Molecular Formula:C16H15NO
Molecular Weight:237.301
Hs Code.:
Mol file:257952-52-6.mol

Synonyms:

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Chemical Property of Oxazole, 4,5-dihydro-4-methyl-2,5-diphenyl-, (4S,5S)-

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Technology Process of Oxazole, 4,5-dihydro-4-methyl-2,5-diphenyl-, (4S,5S)-

There total 6 articles about Oxazole, 4,5-dihydro-4-methyl-2,5-diphenyl-, (4S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 5267-71-0
(1R,2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)benzamide

: 257952-52-6
(4S,5S)-4-methyl-2,5-diphenyl-4,5-dihydro-1,3-oxazole

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); diisopropyl-carbodiimide; In tetrahydrofuran; at 150 ℃; for 0.0833333h; microwave irradiation;
DOI:10.1016/j.tetlet.2004.10.143

Reference yield:

: 79-24-3
Nitroethane

: 100-52-7
benzaldehyde

: 1663-61-2
triethoxymethylbenzene

: 257952-52-6
(4S,5S)-4-methyl-2,5-diphenyl-4,5-dihydro-1,3-oxazole

: (4S,5R)-4-methyl-2,5-diphenyl-2-oxazoline

: (4R,5S)-4-Methyl-2,5-diphenyl-4,5-dihydro-oxazole

Guidance literature:: Nitroethane; benzaldehyde; With Hevea brasiliensis hydroxynitrile lyase; In phosphate buffer; at 20 ℃; for 48h; pH=7;

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 6h;

triethoxymethylbenzene; With trifluoroacetic acid; In 1,2-dichloro-ethane; for 3h; Title compound not separated from byproducts; Heating;
DOI:10.1002/anie.200504230

Reference yield:

: 492-41-1,58550-13-3,757124-50-8
(1R,2S)-norephedrine

: 257952-52-6
(4S,5S)-4-methyl-2,5-diphenyl-4,5-dihydro-1,3-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

2: 63 percent / diisopropyl azodicarboxylate; PPh₃ / tetrahydrofuran / 16 h / 20 °C

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.200504230