4-(4-methoxycarbonyl-phenoxymethyl)-piperidine-1-carboxylic acid t-butyl ester

Base Information

• Chemical Name: 4-(4-methoxycarbonyl-phenoxymethyl)-piperidine-1-carboxylic acid t-butyl ester
• CAS No.: 912946-93-1
• Molecular Formula: C₁₉H₂₇NO₅
• Molecular Weight: 349.427

Synonyms:4-(4-methoxycarbonyl-phenoxymethyl)-piperidine-1-carboxylic acid t-butyl ester

Chemical Property of 4-(4-methoxycarbonyl-phenoxymethyl)-piperidine-1-carboxylic acid t-butyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of 4-(4-methoxycarbonyl-phenoxymethyl)-piperidine-1-carboxylic acid t-butyl ester

There total 4 articles about 4-(4-methoxycarbonyl-phenoxymethyl)-piperidine-1-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) + tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6) → 4-(4-methoxycarbonyl-phenoxymethyl)-piperidine-1-carboxylic acid t-butyl ester (912946-93-1)

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) + tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate (161975-39-9) → 4-(4-methoxycarbonyl-phenoxymethyl)-piperidine-1-carboxylic acid t-butyl ester (912946-93-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 7h;

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) + N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine (166815-96-9) → 4-(4-methoxycarbonyl-phenoxymethyl)-piperidine-1-carboxylic acid t-butyl ester (912946-93-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

upstream raw materials:

methyl 4-hydroxylbenzoate

tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine

Downstream raw materials:

4-(piperidin-4-ylmethoxy)-methyl benzoate

4-[[1-[(2-methylpropan-2-yl)oxycarbonyl]-4-piperidyl]methoxy]benzoic acid

tert-butyl 4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidine-1-carboxylate

1-(2-tert-butylphenyl)-4-{[4-(piperidin-4-ylmethoxy)phenyl]carbonyl}piperazine

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