1-(2-benzyloxy-4-nitro-phenyl)-4-(4,6-dimethyl-pyridin-2-yl)-piperazine

Base Information

• Chemical Name: 1-(2-benzyloxy-4-nitro-phenyl)-4-(4,6-dimethyl-pyridin-2-yl)-piperazine
• CAS No.: 1090513-99-7
• Molecular Formula: C₂₄H₂₆N₄O₃
• Molecular Weight: 418.495
• Mol file: 1090513-99-7.mol

Synonyms:1-(2-benzyloxy-4-nitro-phenyl)-4-(4,6-dimethyl-pyridin-2-yl)-piperazine

Chemical Property of 1-(2-benzyloxy-4-nitro-phenyl)-4-(4,6-dimethyl-pyridin-2-yl)-piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-benzyloxy-4-nitro-phenyl)-4-(4,6-dimethyl-pyridin-2-yl)-piperazine

There total 6 articles about 1-(2-benzyloxy-4-nitro-phenyl)-4-(4,6-dimethyl-pyridin-2-yl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

1-(4,6-dimethyl-pyridin-2-yl)-piperazine (163613-83-0) + 1-chloro-4-nitro-2-(phenylmethoxy)benzene (76464-61-4) → 1-(2-benzyloxy-4-nitro-phenyl)-4-(4,6-dimethyl-pyridin-2-yl)-piperazine (1090513-99-7)

Guidance literature:

With caesium carbonate; palladium diacetate; DavePhos; In toluene; for 20h; Inert atmosphere; Reflux;

Reference yield:

2-chloro-4,6-dimethyl-pyridine (30838-93-8) → 1-(2-benzyloxy-4-nitro-phenyl)-4-(4,6-dimethyl-pyridin-2-yl)-piperazine (1090513-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylene glycol dimethyl ether / 36.5 h / 160 °C

2: caesium carbonate / palladium diacetate; DavePhos / toluene / 20 h / Inert atmosphere; Reflux

With caesium carbonate; palladium diacetate; DavePhos; In diethylene glycol dimethyl ether; toluene;

Reference yield:

2-Amino-4,6-dimethylpyridine (5407-87-4) → 1-(2-benzyloxy-4-nitro-phenyl)-4-(4,6-dimethyl-pyridin-2-yl)-piperazine (1090513-99-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium chloride; sodium nitrite / water / -20 - 20 °C

1.2: bicarbonate

2.1: diethylene glycol dimethyl ether / 36.5 h / 160 °C

3.1: caesium carbonate / palladium diacetate; DavePhos / toluene / 20 h / Inert atmosphere; Reflux

With hydrogenchloride; caesium carbonate; sodium chloride; sodium nitrite; palladium diacetate; DavePhos; In diethylene glycol dimethyl ether; water; toluene;

upstream raw materials:

1-(4,6-dimethyl-pyridin-2-yl)-piperazine

1-chloro-4-nitro-2-(phenylmethoxy)benzene

2-chloro-4,6-dimethyl-pyridine

2-Amino-4,6-dimethylpyridine

Downstream raw materials:

2-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-5-nitro-phenol

acetic acid 2-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-5-nitro-phenyl ester