acetic acid 2-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-5-nitro-phenyl ester

Base Information

Chemical Name:acetic acid 2-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-5-nitro-phenyl ester
CAS No.:1090514-01-4
Molecular Formula:C₁₉H₂₂N₄O₄
Molecular Weight:370.408
Hs Code.:

Synonyms:acetic acid 2-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-5-nitro-phenyl ester

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Chemical Property of acetic acid 2-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-5-nitro-phenyl ester

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Technology Process of acetic acid 2-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-5-nitro-phenyl ester

There total 8 articles about acetic acid 2-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-5-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1090514-00-3
2-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-5-nitro-phenol

: 75-36-5
acetyl chloride

: 1090514-01-4
acetic acid 2-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-5-nitro-phenyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 0.25h;

Reference yield:

: 30838-93-8
2-chloro-4,6-dimethyl-pyridine

: 1090514-01-4
acetic acid 2-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-5-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethylene glycol dimethyl ether / 36.5 h / 160 °C

2.1: caesium carbonate / palladium diacetate; DavePhos / toluene / 20 h / Inert atmosphere; Reflux

3.1: hydrogenchloride / water / 0 - 5 °C / Reflux

3.2: 0 - 5 °C

4.1: triethylamine / dichloromethane

With hydrogenchloride; caesium carbonate; triethylamine; palladium diacetate; DavePhos; In dichloromethane; diethylene glycol dimethyl ether; water; toluene;

Reference yield:

: 5407-87-4
2-Amino-4,6-dimethylpyridine

: 1090514-01-4
acetic acid 2-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-5-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium chloride; sodium nitrite / water / -20 - 20 °C

1.2: bicarbonate

2.1: diethylene glycol dimethyl ether / 36.5 h / 160 °C

3.1: caesium carbonate / palladium diacetate; DavePhos / toluene / 20 h / Inert atmosphere; Reflux

4.1: hydrogenchloride / water / 0 - 5 °C / Reflux

4.2: 0 - 5 °C

5.1: triethylamine / dichloromethane

With hydrogenchloride; caesium carbonate; triethylamine; sodium chloride; sodium nitrite; palladium diacetate; DavePhos; In dichloromethane; diethylene glycol dimethyl ether; water; toluene;