methyl 3-iodo-4-[(N-methoxycarbonyl,N-(2-methyl-2-propenyl))amino]benzoate

Base Information

• Chemical Name: methyl 3-iodo-4-[(N-methoxycarbonyl,N-(2-methyl-2-propenyl))amino]benzoate
• CAS No.: 411233-61-9
• Molecular Formula: C₁₄H₁₆INO₄
• Molecular Weight: 389.19
• Mol file: 411233-61-9.mol

Synonyms:methyl 3-iodo-4-[(N-methoxycarbonyl,N-(2-methyl-2-propenyl))amino]benzoate

Chemical Property of methyl 3-iodo-4-[(N-methoxycarbonyl,N-(2-methyl-2-propenyl))amino]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-iodo-4-[(N-methoxycarbonyl,N-(2-methyl-2-propenyl))amino]benzoate

There total 2 articles about methyl 3-iodo-4-[(N-methoxycarbonyl,N-(2-methyl-2-propenyl))amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Chloro-2-methylpropene (563-47-3) + methyl 3-iodo-4-(N-methoxycarbonyl)aminobenzoate (411233-82-4) → methyl 3-iodo-4-[(N-methoxycarbonyl,N-(2-methyl-2-propenyl))amino]benzoate (411233-61-9)

Guidance literature:

methyl 3-iodo-4-(N-methoxycarbonyl)aminobenzoate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

3-Chloro-2-methylpropene; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

DOI:10.1016/S0040-4020(01)01061-4

Reference yield:

4-amino-3-iodobenzoic acid methyl ester (19718-49-1) → methyl 3-iodo-4-[(N-methoxycarbonyl,N-(2-methyl-2-propenyl))amino]benzoate (411233-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / CH₂Cl₂ / 15 h / 20 °C

2.1: NaH / dimethylformamide / 1 h / 20 °C

2.2: 9.6 g / dimethylformamide / 15 h / 20 °C

With pyridine; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)01061-4

Reference yield: 94.0%

methyl 3-iodo-4-[(N-methoxycarbonyl,N-(2-methyl-2-propenyl))amino]benzoate (411233-61-9) → 3-iodo-4-[methoxycarbonyl-(2-methyl-allyl)-amino]-benzoic acid

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 45 ℃; for 15h;

DOI:10.1016/S0040-4020(01)01061-4

upstream raw materials:

3-Chloro-2-methylpropene

methyl 3-iodo-4-(N-methoxycarbonyl)aminobenzoate

4-amino-3-iodobenzoic acid methyl ester